| 壳聚糖-恶丙嗪缓释片的研制 |
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| 引用本文： | 刘祖雄,李晓东,汤韧,盛莉.壳聚糖-恶丙嗪缓释片的研制[J].中国药房,2001,12(9):532-533. |
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| 作者姓名： | 刘祖雄 李晓东 汤韧 盛莉 |
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| 作者单位： | 广州军区武汉总医院,武汉市,430070 |
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| 摘 要： | 目的：研究壳聚糖－恶丙嗪缓释片的制备、质量标准，并考察体外释药性能。方法：采用紫外分光光度法测定主药恶丙嗪的含量。结果：线性范围为２．５～１５．０ｕｇ／ｍｌ，平均回收率为９９．７９％，ＲＳＤ为０．３８％。结论：该制剂制备工艺简单，值得临床推广应用。
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| 关 键 词： | 壳聚糖 恶丙嗪 缓释片 制备 质量控制 |
| 文章编号： | 1001-0408(2001)09-0532-02 |
| 修稿时间： | 2001年4月23日 |
Preparation of Chitosan-oxaprozin Sustained Release Tablets |
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| LIU Zuxiong,LI Xiaodong,TANG Ren,SHENG Li.Preparation of Chitosan-oxaprozin Sustained Release Tablets[J].China Pharmacy,2001,12(9):532-533. |
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| Authors: | LIU Zuxiong LI Xiaodong TANG Ren SHENG Li |
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| Abstract: | OBJECTIVE: To study the preparation and quality standard of chitosan-oxaprozin sustained release tablets, and observe the rule of in vitro release of oxaprozin. METHODS:The content of oxaprozin in the tablets was determined by UV - spectrophotometry. RESULTS:The linear range was 2. 5- 15. 0ug/ml. The average recovery was 99. 79% with a RSD of 0. 38%. CONCLUSION: The preparation process of chitosan-oxaprozin sustained release tablet is simple. It is worth expanding the app- lication in clinical practice. |
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| Keywords: | chitosan oxaprozin sustained release tablet preparation quality control |
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