Abnormal interleukin-7 function in common variable immunodeficiency |
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Authors: | Holm Are Martin Aukrust Pål Damås Jan Kristian Müller Fredrik Halvorsen Bente Frøland Stig S |
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Affiliation: | Section of Clinical Immunology and Infectious Diseases, Medical Center, Oslo, Norway. a.m.holm@klinmed.uio.no |
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Abstract: | Common variable immunodeficiency (CVID) is characterized by low levels of circulating immunoglobulins, leading to frequent infections, particularly of the respiratory tract. Frequently, T-cell abnormalities are observed. Interleukin-7 (IL-7) is involved in the homeostasis of lymphocytes, and may be elevated in lymphopenia. Mutations of genes related to IL-7 may lead to severe immunodeficiency disorders. We report elevated plasma levels of circulating IL-7 in a subgroup of CVID. These patients have increased numbers of circulating CD8+ T cells with decreased apoptosis and a predominance of CC chemokine receptor 7- (CCR7-) effector-memory T cells. Moreover, in some of these patients there is impaired response to IL-7 as assessed by in vitro proliferation and secretion of interferon gamma and transforming growth factor beta. These findings suggest novel pathogenic mechanisms and specific targets for further research in CVID. |
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