中药辅助治疗肾病综合征的临床疗效观察

目的观察中药辅助治疗肾病综合征的临床疗效。方法 74例原发性肾病综合征患者随机分为对照组和治疗组,每组37例,两组均以激素和细胞毒素作基础治疗,治疗组除基础治疗外,加用红花注射液和六味地黄丸,治疗3个月。观察病情及不良反应等情况,记录治疗前后肾功、血液流变学、血脂和免疫指标。结果两组治疗后各指标值均有所改善,且治疗组各指标改善情况由于对照组。其中,治疗组治疗后24 h尿蛋白、血尿素氮、血肌酐、全血比黏度、血浆比黏度、纤维蛋白原、总胆固醇、三酰甘油、IgM和对照组比较差异具有统计学意义(P0.05)。结论红花注射液和六味地黄丸辅助西医治疗NS可明显改善NS患者的血凝状态、高血脂状态,并减少尿蛋白、提高免疫,对于NS的治疗有很好的辅助作用。

Clinical Efficacy Observation of the Adjuvant Therapy in the Treatment of Nephrotic Syndrome with Chinese Medicine

Objective To observe the clinical efficacy on nephrotic syndrome with adjuvant therapy of Chinese medicine.Methods Seventy-four cases of primary nephrotic syndrome were randomized into a control group and a treatment group,37 cases in each one.The basic treatment with hormone and cytotoxin was applied in the two groups.In the treatment group,Safflower Injection and Liuwei Dihuang Pills were add-ed for 3 months.The sickness condition and adverse reactions were observed.Kidney function and indexes of blood rheology,blood lipid and immunity were recorded before and after treatment.Results Every index was improved after treatment in the two groups and the improvements in the treatment group were better than those in the control group.The differences in the treatment group were significant as compared with the control group after treatment in 24 h urine protein,blood urea nitrogen,serum creatinine,whole blood viscosity,plas-ma viscosity,fibrinogen,total cholesterol,triacylglycerol and IgM（P〈0.05 ）.Conclusion The adjuvant therapy with Safflower Injection and Liuwei Dihuang Pills improves remarkably the states of blood coagulation and hyperlipidemia,reduces urine protein and improves immunity in the patients of nephrotic syndrome.It a-chieves the good adjuvant effect on nephrotic syndrome besides the treatment with western medicine.