| 内皮剥脱后家兔胸主动脉舒张反应的变化 |
| |
| 引用本文： | 刘乃奎,赵民清,唐朝枢,苏静怡.内皮剥脱后家兔胸主动脉舒张反应的变化[J].中国动脉硬化杂志,1995,3(1):59-60. |
| |
| 作者姓名： | 刘乃奎 赵民清 唐朝枢 苏静怡 |
| |
| 作者单位： | 北京医科大学心血管基础研究所病理生理研究室 |
| |
| 摘 要： | 本实验在家兔胸主动脉内皮剥脱模型上，观察血管舒张反应的变化及其与血管平滑肌细胞增殖的关系。结果发现．内皮剥脱后血管对乙酰胆碱的内皮依赖性舒张反应明显降低。术后２周和４周时分别为对照组的２７．７±９．９％和５１．１±１１．４％；实验组和对照组血管对去甲肾上腺素的收缩反应和硝普钠的舒张反应均无显著性差异。内皮剥脱后血管平滑肌细胞显著增殖，内膜增厚。这些结果提示，内皮剥脱后血管的内皮依赖性舒张功能受损，内皮源性舒张因子产生可能减少；血管平滑肌细胞增殖可能与这些变化有关．
|
| 关 键 词： | 主动脉 舒张反应 内皮剥脱 动脉狭窄 |
| 收稿时间： | 1994/12/5 0:00:00 |
| 修稿时间： | 1995/1/19 0:00:00 |
Changes of Vascular Relaxation after Balloon Denudation of the Rabbit Aorta |
| |
| LUI Nai-Kui; ZHAO Min-Qing; TANG Chao-Shu and SU Jing-Yi.Changes of Vascular Relaxation after Balloon Denudation of the Rabbit Aorta[J].Chinese Journal of Arteriosclerosis,1995,3(1):59-60. |
| |
| Authors: | LUI Nai-Kui; ZHAO Min-Qing; TANG Chao-Shu and SU Jing-Yi |
| |
| Institution: | Department of Pathophysiology, Institute of Cardiovascular Research;Beijing Medical University, Beijing 100083,China |
| |
| Abstract: | Changes of vascular relaxation after balloon denudation of the rabbit aorta were investigated. Endothelium-dependent relaxation of ballooninjured vessels to acetylcholine was reduced significantly, 27. 7±9. 9% and 51. 1± 11. 4% of control at 2and 4 weeks after denudation, respectively. However,sodium nitroiprusside-induced relaxation and noradrenaline-induced contractile remained unchanged in the denuded vessel rings. After balloon denudation,vascular smooth muscle cell proliferation increased,and intima thickened. These findings indicated that function of vascular endothelinm-dependent relaxation was injured, and endothelum-derived relaxing factor production may diminished after balloon denudation.Vascular smooth muscle cell proliferation was related to these changes. |
| |
| Keywords: | Denudation Endothelium-dependent relaxation Smooth muscle cell Proliferation |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国动脉硬化杂志》浏览原始摘要信息 |
| 点击此处可从《中国动脉硬化杂志》下载免费的PDF全文 |
