HIV/AIDS致病机理研究进展

目的：对近年来获得性免疫缺陷综合征（Acquired Immunodeficiency Syndrome，AIDS）的致病机理研究进展进行综述。方法：参阅新近公开发表的中外文献阐述了AIDS是由人类免疫缺陷病毒（Human Immunodeficiency Virus，Hiv）引起的一种严重的免疫缺陷性疾病。结果：HIV属于逆转录病毒，由双链RNA、病毒核心蛋白及包膜组成，分为两种类型（HIV-1，HIV-2），绝大多数感染人体的是HIV-1。HIV通过病毒糖蛋白gP^120／gP^41与在被感染细胞的细胞膜表面同时表达的CD4和辅助受体进行识别，从而侵入细胞并损伤宿主的免疫系统，而宿主的免疫应答又不能清除HIV，最终发展成AIDS。结论：HIV感染最终导致机体的免疫功能的损伤，进而发展成AIDS。本文就AIDS致病机理的研究进展做一简要的综述。

Pathogenic Mechanism of HIV/AIDS:Progress in Study

Objective:To review the pathogenic mechanism of acquired immunodeficiency syndrome(AIDS).Methods:The references home and aboard showed that AIDS was a severe immunodeficiency disease caused by infection with HIV.Results:HIV particle was a retrovirus which consisted of two identical strands of RNA,core protein and envelope.HIV was grouped into two categories:HIV-1 and HIV-2.Most bodies were infected by HIV-1.HIV infected cells presenting both CD4 and coreceptor which binded to the viral gp~(120)/go~(41).AIDS developed when HIV destroied the host immune system while the host immune response could not eradicate HIV infection.Conclusion:HIV infection destroies the immune system and develops AIDS.This paper reviews the studies on pathogenic mechanism of AIDS.