Human antibody response towards the pneumococcal surface proteins PspA and PspC during invasive pneumococcal infection |
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Authors: | Linder Adam Hollingshead Susan Janulczyk Robert Christensson Bertil Akesson Per |
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Affiliation: | Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, SE-221 85 Lund, Sweden. |
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Abstract: | IgG antibodies against pneumococcal surface protein A, family 1 (PspA1) and family 2 (PspA2), protein C (PspC), and protein Hic were investigated in 41 patients with invasive pneumococcal disease. Pre-existing antibody levels against the four pneumococcal proteins were not significantly different from those found in 40 patients with non-pneumococcal bacteremia or 80 healthy controls. However, during convalescense a strong immune response developed especially against PspA, and there was a high degree of cross-reactivity between PspA- and PspC-antibodies. Our findings on immunogenicity and cross-reactivity suggest that in a future pneumococcal protein based vaccine, only a limited number of proteins could be sufficient. |
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