| 成人急性淋巴细胞白血病免疫表型特点分析 |
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| 引用本文： | 满秋红,邱立娟,刘铁强,胡楷勋,黄珊,孙雪东.成人急性淋巴细胞白血病免疫表型特点分析[J].中国体视学与图像分析,2008,13(4). |
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| 作者姓名： | 满秋红 邱立娟 刘铁强 胡楷勋 黄珊 孙雪东 |
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| 作者单位： | 解放军307医院血液科,北京丰台区东大街8号,北京100071 |
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| 基金项目： | 全军医药卫生科研指令课题 |
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| 摘 要： | 目的研究成人急性淋巴细胞白血病(ALL)患者中不同亚型的各种白血病细胞免疫表型分布特点。方法采用当前国际通用的四色流式细胞术图像分析系统检测并综合分析76例ALL患者的免疫表型及其发生规律与特点。结果①76例ALL免疫表型系列来源可分为三种不同亚型,其中T-ALL亚型5例(占6.57%)、B-ALL亚型68例(89.48%)、T和B细胞混合型(T/B-ALL)亚型3例(3.95%)②ALL早期抗原表达特点:在B-ALL亚型中CD38、CD34、HLA-DR呈高表达;在T-ALL亚型中,CD38和CD34呈高表达,但HLA-DR不表达;在T/B-ALL亚型中,HLA-DR表达,CD34和CD38不表达。③按免疫分型相关抗原的敏感性和特异性分析:在B-ALL中,特异性抗原cCD79a占91.18%,敏感性抗原CD19表达占97.06%;在T-ALL中,特异性抗原cCD3和敏感性抗原CD7均表达为100%;在T/B混合型ALL中,cCD3、cCD79a、CD19均表达,CD7表达2例;④伴髓系抗原交叉表达分析:在B-ALL中,伴髓系抗原表达占21例(30.88%);在T-ALL中,伴髓系抗原表达1例(20%);T/...
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| 关 键 词： | 急性淋巴细胞白血病 免疫表型 四色流式细胞术 |
Immunophenotype feature analysis of 76 cases of adult acute lymphoblastic leukemia |
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| MAN Qiuhong,QIU Lijuan,LIU Tieqiang,HU Kaixun,HUANG Shan,SUN Xuedong.Immunophenotype feature analysis of 76 cases of adult acute lymphoblastic leukemia[J].Chinese Journal of Stereology and Image Analysis,2008,13(4). |
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| Authors: | MAN Qiuhong QIU Lijuan LIU Tieqiang HU Kaixun HUANG Shan SUN Xuedong |
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| Institution: | MAN Qiuhong; QIU Lijuan; LIU Tieqiang; HU Kaixun; HUANG Shan; SUN Xuedong (Affiliated Hospital; Academy of Military Medical Sciences; Beijing 100071; China); |
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| Abstract: | Objective To analyze the immunophenotype features of the subtypes of adult acute lymphoblastic leukemia(ALL).Methods 76 cases of ALL were evaluated and classified by immunomarkers expression of cells using tetrachromatic flow cytometry.Results The 76 patients were identified into T-ALL(6.57%),B-ALL(89.47%) T/B mixed ALL(3.95%) according to immunophenotype lineage of leukemia.The patients were analyzed with earlier stage lineage unrelated antigens expression features: B-ALL expressed CD38,CD34 and DR;T-ALL e... |
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| Keywords: | flow cytometry immunophenotype acute lymphoblastic leukemia |
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