Lymphocyte responses in acute coronary syndromes: lack of regulation spawns deviant behaviour. |
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Authors: | Giuseppina Caligiuri Antonino Nicoletti |
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Institution: | Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris6, Inserm UMR S 681, 15 rue de L'Ecole de Medecine, Paris F-75006, France |
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Abstract: | The inflammatory and immune systems are abnormally activatedduring the acute phases of coronary atherosclerotic disease.1,2In particular, an unusual population of effector cells, lackingcostimulatory molecule CD28, is transiently expanded in parallelwith the occurrence of the waxing phases of atheroscleroticcoronary disease.3 The origin of the lymphocyte response in acute coronary syndromeshas been a matter of debate in the last decade. Questions stillovercome the answers. It has been demonstrated that the T-cellresponse can be directed to restricted antigens within the |
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