人参茎叶皂甙和人参根皂甙及赛庚啶对大鼠主动回避反应的影响

本文研究了人参茎叶皂甙（ＧＳＬＳ）和人参根皂甙（ＧＲＳ）及赛庚啶（ＣＹＤ）对大鼠穿梭箱主动回避反应的影响学习和记忆成绩用回避反应率（ＡＲ）和回避潜伏期（ＡＬ）评价．多次用药后，ＧＳＬＳ３０ｍｇ／ｋｇ通过显著增加ＡＲ和显著缩短ＡＬ而易化了１０月龄雄性Ｗｉｓｔａｒ种鼠单路回避反应的学习和记忆获得，但损害了雄性大鼠双路回避反应的学习获得．多次腹腔注射ＧＳＬＳ３０ｍｇ／ｋｇ和ＧＲＳ４０ｍｇ／ｋｇ均相似显著改善了由东莨菪碱（０．８ｍｇ／ｋｇ）损害的Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠单路回避反应的学习和记忆获得．此处，单次腹腔注射ＣＹＤ０．５ｍｇ／ｋｇ通过显著减少ＡＲ和显著延长ＡＬ而损害了雄性Ｗｉｓｔａｒ大鼠双路回避反应的学习的记忆获得．

EFFECTS OF GINSENG STEM-LEAF SAPONINS AND GINSENG ROOT SAPONINS AND CYPROHEPTADINE ON ACTIVE AVOIDANCE RESPONDING IN RATS

he effects of ginseng stem-leaf saponins (GSLS)and ginseng root saponins(GRS)andcyproheptadie(CYP)on learning and memory in male rats were examined using a shuttlebox active avoidance method. Learning and memory were estimated by the avoidance rate(AR)and avoidance iatency (AL).Repeated administration of GSLS (30mg/kg ip)signifi-cantly facilitated the learning and memory acquisition of oneway avoidance in 10 month oldmale Wistar rats by increasing the AR and/or shortening the AL,but impaired the learningacquisition of two-way-avoidance in Wistar rats. Repeated administration GSLS 30 mg/kgand GRS 40 mg/kg ip produced a similarly significant improvement in the learning and mem-ory acquisitional deficits of one-way avoidance in Sprague-Dawley rats induced by scopo-lamine(0. 8mg/kg sc). Furthermore,acute administration of CYP 0.5 mg/kg ip impaired thelearning and memory acquisition of two-way avoidance in Wistar rats significantly by de-creasing the AR and/or prolonging the AL.