| 3′(5α-3β,17β-双羟基-雄甾烷-17α)-丙酸内酯(Ⅴ)的微生物转化——螺旋内酯甾(Ⅱ)的合成 |
| |
| 引用本文： | 殷芝华,张丽青,周维善. 3′(5α-3β,17β-双羟基-雄甾烷-17α)-丙酸内酯(Ⅴ)的微生物转化——螺旋内酯甾(Ⅱ)的合成[J]. 药学学报, 1980, 15(12): 730-735 |
| |
| 作者姓名： | 殷芝华 张丽青 周维善 |
| |
| 作者单位： | 中国科学院上海有机化学研究所 |
| |
| 摘 要： | 3′-(5α-3β,17β-双羟基-雄甾烷-17α)-丙酸内酯(Ⅴ)经诺卡氏菌(Nocardia sp.)转化获得6个化合物(Ⅱ和Ⅵ～Ⅹ),其中螺旋内酯甾(Ⅱ)为其主要产物(～50%)。Ⅷ～Ⅹ是尚未被鉴定的羟基化合物。化合物(Ⅴ)用诺卡氏菌在氮源贫乏的培养基中转化主要生成△4-3-酮化合物,而在氮源丰富的培养基中转化则主要为△1,4-3-酮的产物。
|
| 收稿时间： | 1979-09-06 |
MICROBIOLOGICAL DEHYDROGENATION OF 3′-(5α, 3β, 17β-DIHYDROXY-ANDRASTANE-17α)-PROPIOLACTONE (V) BY NOCARDIA SP -SYNTHESIS OF SPIROLACTONE(Ⅱ) |
| |
| Yin Zhihua,Zhang Liqing and Zhou Weishan. MICROBIOLOGICAL DEHYDROGENATION OF 3′-(5α, 3β, 17β-DIHYDROXY-ANDRASTANE-17α)-PROPIOLACTONE (V) BY NOCARDIA SP -SYNTHESIS OF SPIROLACTONE(Ⅱ)[J]. Acta pharmaceutica Sinica, 1980, 15(12): 730-735 |
| |
| Authors: | Yin Zhihua Zhang Liqing Zhou Weishan |
| |
| Abstract: | Incubation of 3'-(5α, 3β, 17β-dihydroxy-androstane-17α)-Propiolactone (Ⅴ) with Nocardia sp. afforded 6 compounds (Ⅱ and Ⅵ～Ⅹ), among which spirolactone (Ⅱ) was. the major product (～50%). Ⅷ～Ⅹ were unidentified hydroxy compounds. The △4-3-keto compound (Ⅱ) is the main product when the medium is poor in nitrogen. |
| |
| Keywords: | |
|
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
