| 氯胺酮应用于超前镇痛的临床研究进展 |
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| 引用本文： | 陶利军,张宏.氯胺酮应用于超前镇痛的临床研究进展[J].医学综述,2006,12(4):242-244. |
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| 作者姓名： | 陶利军 张宏 |
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| 作者单位： | 中国人民解放军总医院麻醉科,北京,100853 |
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| 摘 要： | 实验证明N-甲基-D-天冬氨酸(NMDA)受体的激活与痛阈降低和中枢敏感化有关,全身或鞘内应用NMDA拮抗剂可抑制伤害性反应,拮抗痛阈降低和防止或逆转中枢敏感化;NMDA受体非竞争性拮抗剂氯胺酮在临床已用于急慢性疼痛的治疗,关于其在超前镇痛的作用基础与临床作了大量研究,但结果并不一致;本文就其最新临床研究进展予以综述。
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| 关 键 词： | 镇痛 超前镇痛 氯胺酮 |
| 文章编号： | 1006-2084（2006）04-0242-03 |
| 收稿时间： | 2005-08-09 |
| 修稿时间： | 2006-01-25 |
The Progress in Clinical Study of Preemptive Analgesia Using |
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| TAO Li-jun,ZHANG Hong.The Progress in Clinical Study of Preemptive Analgesia Using[J].Medical Recapitulate,2006,12(4):242-244. |
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| Authors: | TAO Li-jun ZHANG Hong |
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| Institution: | Department of Anesthesiology General Hospital of PIA, Beijing 100853, China |
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| Abstract: | The experiments have proved that the activation of N-methyl-Daspartate(NMDA)receptor was responsible for the decreasion of pain threshold and central sensitization.NMDA receptor antagonist that was administered systemically or intrathecally can inhibit nociceptive effect,competitive inhibit the decreasion of pain threshold and prevent or reverse central sensitization.Ketamine is a NMDA receptor noncompetitive antagonist,which has been administered clinically to treat acute or chronic pain syndrome.A lot of study have been carried about its effect of preemptive analgesia,but we have different results.So this article summarized the progress about this drug in clinical research in recent years. |
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| Keywords: | Analgesia Preemptive analgesia Ketamine |
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