细胞因子对青光眼滤过手术瘢痕化调控的研究进展

手术后瘢痕化是导致青光眼滤过手术失败的主要原因。多种细胞因子，如转化生长因子β（TGF-β）、血管内皮生长因子（VEGF）、结缔组织生长因子（CTGF）、白细胞介素（IL-1）和干扰素（INF）等参与青光眼滤过手术瘢痕化过程的调控。目前已研制出多种针对这些细胞因子的治疗性干预措施，在预防青光眼手术滤过通道瘢痕化方面具有很好的应用前景。本文对参与调控青光眼滤过手术瘢痕化的细胞因子以及针对性治疗措施进行综述。

Cytokines in scar regulation after glaucoma filtration surgery

Following all types of glaucoma filtration surgery, scarring still poses the major threat to long-term success. Many cytokines, such as transforming growth factor-β（TGF-β） , vascular endothelial growth factor （VEGF） , connective tissue growth factor （CTGF） , interleukin （IL） and interferon （INF） , are associated with the scarring progress after filtration surgery. Recently, many promising new agents were used therapeutically by binding to these molecular targets among sear regulation after glaucoma surgery. In this review, we discuss our current understanding of cytokines in the wound healing process after glaucoma surgery and promising new treatment modalities.