中老年2型糖尿病患者认知功能的影响因素分析

目的:评估中老年2型糖尿病患者的认知功能并了解其相关的影响因素。方法:选择中老年有2型糖尿病病史患者(年龄40~69岁)199例。调查患者既往病史、糖尿病病程、家族史,检测并比较所有入组患者的体质量指数(BMI)、腰臀比(WHR)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血脂、血压及颈动脉彩色超声。选用蒙特利尔认知评估(MoCA)量表北京版进行认知功能的评估。结果:糖尿病病程5年以上的患者MoCA评分较5年以内者降低(P<0.05)。认知功能与受教育年限、高血压病史、WHR、FPG、HbA1c、颈动脉内膜中层厚度(IMT)、颈动脉阻力指数(RI)显著相关(P<0.05)。多元回归分析显示,受教育年限、高血压病史、颈动脉RI、HbA1c是影响糖尿病患者MoCA评分水平的关键因素。结论:中老年2型糖尿病患者的认知功能与其受教育程度、高血压病史、颈动脉血管阻力及血糖控制情况密切相关。

Influencing factors of cognitive function in middle-aged patients with type 2 diabetes mellitus

Objective To study the influencing factors of cognitive function in middle-aged patients with type 2 diabetes mellitus. Methods Montreal cognitive assessment （MoCA） （Beijing version） was applied for assessment of cognitive function. One hundred and ninety-nine type 2 diabetes patients （40-69 years old） were enrolled. Disease course, family history of diabetes, and data of body mass index （BMI）, waist-hip ratio （WHR）, fasting plasma glucose （FPG）, hemoglobin Ak（HbAk）, blood pressure, blood lipids and carotid ultrasound were collected. Results Patients with duration of diabetes 〉5 years had lower MoCA score than those 〈 5 years. Cognitive function was positively correlated with years of education, and negatively correlated with the history of hypertension, WHR, FPG, HbAk, carotid artery intima-media thickness and carotid artery resistant index （RI）（P〈0.05）. Multiple regression analysis showed that history of hypertension, carotid artery RI and HbAk were the significant independent determinants for MoCA score. Conclusions Years of education, history of hypertension, carotid artery RI and glucose regulation were the influencing factors of cognitive function in middle-aged type 2 diabetes patients.