| 白藜芦醇对糖尿病大鼠肾脏内氧化应激的影响 |
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| 引用本文： | 丁洪成,程长明,廖勇敢. 白藜芦醇对糖尿病大鼠肾脏内氧化应激的影响[J]. 成都中医药大学学报, 2009, 32(1): 62-65 |
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| 作者姓名： | 丁洪成 程长明 廖勇敢 |
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| 作者单位： | 郧阳医学院,附属人民医院内分泌科,湖北,十堰,442000;郧阳医学院,附属人民医院内分泌科,湖北,十堰,442000;郧阳医学院,附属人民医院内分泌科,湖北,十堰,442000 |
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| 摘 要： | 目的：观察白藜芦醇对糖尿病大鼠肾脏内氧化应激（OS）的影响。方法：将实验动物分为正常对照组、糖尿病组、白藜芦醇治疗组。建立糖尿病大鼠模型,检测各组成模12周后肾组织中丙二醛（MDA）含量、铜,锌-超氧化物歧化酶（Cu,Zn-SOD）、谷光甘肽过氧化酶（GSH-Px）活性,同时观察肾功能、尿蛋白和肾脏形态。结果：与糖尿病组相比,白藜芦醇治疗组肾脏MDA含量明显下降,而肾脏抗氧化酶活性（Cu,Zn-SOD、GSH-PX）则显著上升,肾功能和肾脏形态均明显改善,尿蛋白下降。结论：氧化应激在2型糖尿病肾脏损害过程中发生了重要作用;白藜芦醇通过抑制氧化应激达到了其对该模型大鼠肾脏的保护作用。
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| 关 键 词： | 白藜芦醇 糖尿病肾病 氧化应激 |
Effect of Resveratrol on Oxidative Stress in Type 2 Diabetic Rats |
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| Ding hong-cheng,Cheng chang-ming,et al. Effect of Resveratrol on Oxidative Stress in Type 2 Diabetic Rats[J]. Journal of Chengdu University of Traditional Chinese Medicine, 2009, 32(1): 62-65 |
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| Authors: | Ding hong-cheng Cheng chang-ming et al |
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| Affiliation: | Department of Endocrinology;People Hospital affiliated Yunyang Medical College;Shiyan;Hubei;442000 |
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| Abstract: | Objective: To evaluate effect of resveratrol on oxidative stress in renal in type 2 diabetic rats.Methods: Thirty Wistar rats(male) were divided into three groups of normal rats,diabetic rats,diabetic rats treated with resveratrol(30mg/ kg/ d).After 12 weeks,Serum creatinine,blood urea nitrogen,24h urinary albumin,lipid peroxidatin(MDA),the activity of antioxidant enzymes including Cu,Zn-superoxide dismutase(Cu,Zn-SOD) and glutathione peroxidase(GSH-Px) in the renal tissue were measured.In addition,the rena... |
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| Keywords: | resveratrol Diabetic Nephropathy Oxidative Stress |
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