| 水蛭素对荷肝癌H22小鼠的抑瘤作用 |
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| 引用本文： | 姚娓,张红,鲍发臻,刘勇,贾爱明. 水蛭素对荷肝癌H22小鼠的抑瘤作用[J]. 中国医院用药评价与分析, 2011, 0(12): 1105-1107 |
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| 作者姓名： | 姚娓 张红 鲍发臻 刘勇 贾爱明 |
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| 作者单位： | 大连医科大学附属第二医院中医科;大连医科大学附属第一医院中医科; |
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| 摘 要： | 目的:观察水蛭素对肝癌H22荷瘤小鼠的抑瘤作用。方法:小鼠右前腋窝下皮下种瘤造成实体瘤模型,将40只小鼠随机抽样分为4组,水蛭素高剂量和水蛭素低剂量组、氟尿嘧啶组及模型对照组,每组10只。治疗期间记录各组小鼠的体重变化并观察小鼠生存状态,用药14 d后取瘤称重,计算抑瘤率,并计算肝/体比、肾/体比、脾脏指数以及用药前后的体重变化等指标。结果:水蛭素高、低剂量组对小鼠H22肝癌细胞均有明显的抑制作用,抑瘤率分别为37.63%、23.71%,与模型对照组比较,差异有统计学意义(P<0.01、P<0.05),水蛭素高、低剂量组与氟尿嘧啶组比较,肝/体比、肾/体比、脾脏指数均有显著性差异,有统计学意义(P<0.05),经治疗后水蛭素各组小鼠与模型对照组及治疗前比较体重变化不明显(P>0.05)。结论:水蛭素对小鼠H22肝癌细胞有明显的抑制作用,同时对小鼠重要器官可能具有一定的保护作用。
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| 关 键 词： | 水蛭素 H22肝癌 氟尿嘧啶 抑瘤 |
Antitumor Effect of Hirudin in Mice Bearing H22 Hepatocellular Carcinoma |
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| YAO Wei,ZHANG Hong,BAO Fa-zhen,LIU Yong,JIA Ai-ming. Antitumor Effect of Hirudin in Mice Bearing H22 Hepatocellular Carcinoma[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2011, 0(12): 1105-1107 |
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| Authors: | YAO Wei ZHANG Hong BAO Fa-zhen LIU Yong JIA Ai-ming |
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| Affiliation: | YAO Wei1,ZHANG Hong1,BAO Fa-zhen1,LIU Yong2,JIA Ai-ming1(1.Dept.of Traditional Chinese Medicine,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,China,2.Dept.of Traditional Chinese Medicine,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,China) |
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| Abstract: | OBJECTIVE: To evaluate the antitumor effect of hirudin on H22 tumor cells in mice.METHODS: 40 mice were injected with H22 hepatoma cells from their right axillae to establish solid tumor model before being randomly divided into 4 groups of 10 each: high dose hirudin group,and low dose hirudin group,5-FU group and model control group.The body weight and survival of mice in all groups were recorded.After exposing to medications for 14 days,the tumors were taken out and weighted with tumor inhibition rate,live... |
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| Keywords: | Hirudin Hepatic carcinoma 5-FU Tumor inhibition |
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