321例药品不良反应报告分析

目的:掌握广西壮族自治区南溪山医院药品不良反应(ADR)的发生特点,为临床合理用药提供参考。方法:对2006年1月—2010年12月收集的321例ADR报告,按患者性别、年龄、给药途径、ADR程度、药品类别、涉及器官和(或)系统以及临床表现等进行统计、分析。结果:321例ADR中,19～44岁年龄段患者ADR发生率较高(113例,占35.2%),男性与女性间无差异;静脉给药方式是导致ADR的重要途径(248例,占77.3%);ADR发生率最高的为抗感染药(139例,占43.3%),其次是消化系统用药及中药制剂;临床表现以皮肤及其附件损害最常见(163例,占50.8%),其次是全身性损害。结论:应加强抗菌药物及中药制剂的合理使用与管理,以减少ADR发生;同时加强ADR监测的培训工作,提高上报意识,完善并提高ADR报告质量。

Adverse Drug Reaction: Analysis of 321 Cases

OBJECTIVE： To probe into the characteristics of adverse drug reactions（ADRs） occurred in Nanxishan Hospital of Guangxi Zhuang Autonomous Region for clinical reference of rational drug use.METHODS： A total of 321 ADR case reports collected from Jan.2006 to Dec.2010 were analyzed statistically with regard to patients’age and sex,route of administration,severity of ADR,drug categories,organs or systems involved and clinical manifestations.RESULTS： Of the 321 ADR cases,113（35.2%） were patients aged 19-44 years yet without gender difference;248（77.3%） were induced via intravenous administration;anti-infective agents had the highest ADR incidence（139 cases/43.3%） followed by digestive medicine and Chinese herbal preparations.The ADR manifested predominantly as lesions of skin and its appendages（50.8%） followed by systemic lesions.CONCLUSION： Rational use and management of antibiotics and Chinese herbal preparations should be strengthened to reduce the occurrence of ADR.The training on ADR monitoring and the ADR reporting awareness should be emphasized,and the quality of ADR reports should be improved as well.