| 222例抗肿瘤药致不良反应报告分析 |
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| 引用本文： | 章娟,吴洪斌,翟青.222例抗肿瘤药致不良反应报告分析[J].中国医院用药评价与分析,2011(10):937-940. |
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| 作者姓名： | 章娟 吴洪斌 翟青 |
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| 作者单位： | 复旦大学附属肿瘤医院药剂科复旦大学上海医学院肿瘤学系; |
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| 摘 要： | 目的:了解复旦大学附属肿瘤医院抗肿瘤药致不良反应(ADR)的发生情况,探讨其发生规律,指导临床合理用药,保证用药安全有效。方法:对2009年1月—2010年12月上报的222例抗肿瘤药发生的ADR进行统计、归纳和分析。结果:ADR的发生女性多于男性,41～60岁患者居多;消化系统肿瘤105例(47.30%),女性生殖系统肿瘤59例(26.58%),乳腺癌36例(16.21%);222例报告涉及到14种药品,铂类药有146例(65.77%),紫杉醇类药有49例(22.07%),卡培他滨12例(5.41%);神经系统损伤84例(25.53%),循环系统损伤74例(22.50%),皮肤及其附件损伤66例(20.06%)。219例(98.65%)属一般性ADR,程度均为轻至中度,其中发生率居前3位的临床表现为胸闷、潮红和瘙痒;严重的ADR有3例,表现为过敏性休克2例(分别由紫杉醇注射液和注射用盐酸吉西他滨(健择)引起)和心脏停搏、昏厥1例(由注射用奥沙利铂引起)。结论:应高度重视肿瘤患者的ADR监测工作,尤其要注意铂类药和紫杉醇类药引起的ADR,及时预防、上报和更新ADR,为抗肿瘤药的合理应用提供依据,降低其ADR的发生率,进一步提高药物治疗效果,改善肿瘤患者的生活质量。
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| 关 键 词： | 抗肿瘤药 不良反应 分析 合理用药 |
Antineoplastic Agents-induced Adverse Drug Reaction: Analysis of 222 Cases |
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| ZHANG Juan,WU Hong-bin#,ZHAI Qing.Antineoplastic Agents-induced Adverse Drug Reaction: Analysis of 222 Cases[J].Evaluation and Analysis of Drug-Use in Hospital of China,2011(10):937-940. |
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| Authors: | ZHANG Juan WU Hong-bin# ZHAI Qing |
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| Institution: | ZHANG Juan*,WU Hong-bin#,ZHAI Qing(Dept.of Pharmacy,Fudan University Affiliated Cancer Hospital,Department of Oncology,Shanghai Medical College of Fudan University,Shanghai 200032,China) |
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| Abstract: | OBJECTIVE: To probe into the prevalence and regularity of antineoplastic agents-induced adverse drug reaction(ADR) in Fudan University Affiliated Cancer Hospital in order to provide guidance for clinical rational drug use and ensure safe and effective drug use.METHODS: A total of 222 cases of antineoplastic agents-induced ADR reported between Jan.2009 and Dec.2010 were analyzed statistically.RESULTS: The ADR occurred prominently in females and in patients aged 41-60 years.Of the 222 cases,105(47.30%) had di... |
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| Keywords: | Antineoplastic agents Adverse drug reaction Analysis Rational drug use |
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