诱生型一氧化氮合酶在骨关节炎发病机制中的作用探讨

目的 探讨骨关节炎(OA)患者关节滑膜中诱生型一氧化氮合酶(iNOS)的表达及在OA发病机制中的作用.方法 采用免疫组织化学方法检测OA患者关节滑膜组织中iNOS的表达.结果 OA滑膜HE染色显示滑膜细胞由单细胞层变成多细胞层并有炎症细胞浸润和血管增生与扩张;滑膜免疫组织化学染色显示滑膜细胞质内有棕黑色颗粒沉积.结论 iNOS及其产生的NO可能参与了OA的病变过程,是OA病程发展的机制之一.

Effects of inducible nitric oxide synthase on mechanism of osteoarthritis

Objective To observe the expression of inducible nitric oxide synthase (iNOS) in synovium of osteoarthritis and to investigate the relationship with the disease.Methods iNOS expression is investigated by means of immunohistochemical assay.Results By immunohistochemical assay , we found that there are significant expression of iNOS in synovium of osteoarthritis patients than that of control.Conclusion In OA ,there are high expression of iNOS in synovium ,so we concluded that iNOS may mediate the pathogenesis and development of OA.