| 用图像分析法研究银屑病表皮热休克蛋白的表达 |
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| 引用本文： | 庞晓文,杨雪琴,孟如松,李世荫,施华强. 用图像分析法研究银屑病表皮热休克蛋白的表达[J]. 中国体视学与图像分析, 1999, 0(3) |
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| 作者姓名： | 庞晓文 杨雪琴 孟如松 李世荫 施华强 |
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| 作者单位： | 解放军空军总医院皮肤科!北京100036(庞晓文，杨雪琴，孟如松)，北京医科大学第三医院皮肤科!北京100083(李世荫)，解放军空军总医院病理科!北京100036(施华强) |
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| 摘 要： | 目的 :了解热休克蛋白在银屑病表皮异常增生分化中的作用。方法 :采用免疫组化和图像定量分析技术研究银屑病皮损、非皮损表皮中热休克蛋白 (HSP2 7,HSP70 )含量的变化。结果 :正常人组和银屑病非皮损组表皮HSP2 7和HSP70的含量均明显高于银屑病皮损组 (P <0 0 1) ,而正常人组与银屑病非皮损组相比 ,两者含量无显著性差异 (P >0 0 5 )。结论 :热休克蛋白在银屑病发病中具有重要作用。而图像定量分析技术则大大提高了结果的可靠性和客观性。
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| 关 键 词： | 银屑病 免疫组化 图像定量分析 热休克蛋白 |
Image analysis study on expression of heat shock proteins in psopiatic epidermis |
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| Pang Xiaowen Yang Xueqin Meng Rusong et al. Image analysis study on expression of heat shock proteins in psopiatic epidermis[J]. Chinese Journal of Stereology and Image Analysis, 1999, 0(3) |
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| Authors: | Pang Xiaowen Yang Xueqin Meng Rusong et al |
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| Abstract: | Objective To observe the pathogenetic action of heat shock proteins in abnormal epidermal proliferation and defective differentiation of psoriasis. Methods By means of immunohistochemical and image analysis techniques the expression of heat shock proteins(HSP27, HSP70) in psoriatic lesion and normal skin (24 cases)were measured. Result In epidermis of psoriatic lesions, compared with the normal skin and psoriatic non damaged skin, the contents of HSP27 and HPS70 were both obviously reduced, the differences were highly significant (P<0 01). And the contents of HSP27 and HSP70 between the normal and psoriatic non damaged skin were not significantly different (P>0 05) Conclusions Heat shock proteins may play an important rolein the pathogenesis of psoriasis. And image analysis may be a very useful method to enhance the reliability and objectivity for investigation. |
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| Keywords: | psoriasis immunohistochemistry image analysis heat shock protein |
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