Attachment reaction of rat uterine luminal epithelium V. Suppression of the attachment reaction by some antifertility agents |
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Authors: | Ingvar Ljungkvist and Lars Terenius |
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Affiliation: | a Department of Anatomy, University of Uppsala, Trädgårdsgatan 20, S752 20, Uppsala, Sweden b Department of Pharmacology, University of Uppsala, Biomedical Centre, Box 573, S751 23, Uppsala, Sweden |
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Abstract: | The effects of the postcoitally active antifertility agents U-11,555A, U-11,100A, MER-25, ICI-46,474, 66/179, F-6103, F-6255, F-6278 and ORF-4563 on the ultrastructure of the rat uterine luminal epithelium were studied in spayed, virgin rats under three experimental conditions. - 1. Expt. I. When given separately, all agents gave an estrogen-like response. This was most marked with the F-compounds and ORF-4563.
- 2. Expt. II. In progesterone-treated rats, the F-compounds and ORF-4563 changed the ultrastructure profoundly, while the other compounds had little effect.
- 3. Expt.III. A combination of progesterone and estradiol renders the epithelium suitable for implantation; a parallel change in the ultrastructure is the attachment reaction.
When given before estradiol, each compound except U-11,555A inhibited the attachment reaction in most animals.In conclusion, the F-compounds and ORF-4563 had strong estrogenic effects in all tests. Their antifertility activity is probably related to this property. The other substances were almost indistinguishable from estradiol in Expt. I but did not induce an attachment reaction in Expt. II as estradiol does. In Expt. III these substances, except U-11,555A, seemed to act like anti-estrogens, interfering with the attachment-inducing effect of estradiol, which may explain their antifertility activity. How U-11,555A exerts its antifertility activity is not clear. |
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