| 壳聚糖/介孔生物活性玻璃多孔膜的制备和表征 |
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| 引用本文： | 贾天保,陈建勇,冯新星,常江. 壳聚糖/介孔生物活性玻璃多孔膜的制备和表征[J]. 中国神经再生研究, 2011, 15(42): 7877-7880 |
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| 作者姓名： | 贾天保 陈建勇 冯新星 常江 |
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| 作者单位： | 浙江理工大学“先进纺织材料与制备技术”教育部重点实验室，材料与纺织学院，浙江省杭州市 310018,浙江理工大学“先进纺织材料与制备技术”教育部重点实验室，材料与纺织学院，浙江省杭州市 310018,1浙江理工大学“先进纺织材料与制备技术”教育部重点实验室，材料与纺织学院，浙江省杭州市 310018；2中国科学院上海硅酸盐研究所，上海市 200050,中国科学院上海硅酸盐研究所，上海市 200050 |
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| 基金项目： | 国家自然科学基金项目（面上项目，重点项目，重大项目）;国家杰出青年科学基金 |
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| 摘 要： | 背景：壳聚糖和介孔生物玻璃都具有良好的生物相容性和止血性能，但壳聚糖止血作用有限，介孔生物玻璃粉体方式止血，给应用带来不便。目的：制备壳聚糖/介孔生物玻璃复合多孔膜并检测材料的性能。方法：采用冷冻干燥法制备壳聚糖/介孔生物玻璃复合多孔膜。结果与结论：通过冷冻干燥法可以实现壳聚糖和介孔生物玻璃的均匀复合。制备的复合多孔膜的孔隙分布较均匀；多孔膜具有很好的吸水性，吸水率的大小与壳聚糖和介孔生物玻璃质量比相关；多孔膜的孔隙率高。
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| 关 键 词： | 介孔生物玻璃；壳聚糖；冷冻干燥；多孔膜；止血 |
Fabrication and characterization of chitosan/mesoporous bioactive glasses porous films |
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| Affiliation: | Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China,Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China,1Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China; 2Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China,Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China |
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| Abstract: | BACKGROUND: Chitosan (CS) and mesoporous bioactive glasses (MBG) have some good properties, such as biocompatibility and hemostasis, but the hemostatic effect of CS is limited and it is inconvenient to use the MBG directly.OBJECTIVE: To prepare CS/MBG porous filmsMETHODS: CS and MBG porous film was prepared through a freeze drying process. The prepared porous films were characterized by using Fourier transform infrared spectroscopy, scanning electron microscope and X-ray diffraction. In addition, water adsorption, swelling ratio, the porosity and the mechanical property of the porous films were also studied.RESLUTS AND CONCLUSION: CS/MBG could be blended homogeneously via the lyophilization. The hole of the porous films was relatively uniform. The porous films showed good water adsorption character, which could be modulated by varying the weight ratio of CS and MBG. The prepared porous films had a higher porosity. The composite films can be potentially applied as a wound dressing material. |
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| Keywords: | Chitosan mesoporous bioactive glasses porous films |
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