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| 部队医院多药耐药鲍氏不动杆菌主要流行克隆谱系的分析 | |
| 引用本文： | 董喆,丁志平,徐雅萍,闫中强,沈定霞. 部队医院多药耐药鲍氏不动杆菌主要流行克隆谱系的分析[J]. 中华医院感染学杂志, 2011, 21(24): 5118-5121 |
| 作者姓名： | 董喆 丁志平 徐雅萍 闫中强 沈定霞 |
| 作者单位： | 1. 解放军总医院南楼临床部感染管理科 2. 解放军总医院南楼临床部感染检验科 3. 解放军总医院南楼医技部微生物科,北京,100853 |
| 摘 要： | 目的 了解我国部队医院中多药耐药鲍氏不动杆菌的主要流行克隆谱系,揭示分子流行的趋势.方法 基于鲍氏不动杆菌的靶标基因ompA、csuE和blaOXA-51-like设计2组特异性引物,并建立了基于序列分型的多重PCR方法；进一步选用该方法鉴定多药耐药鲍氏不动杆菌的主要流行克隆谱系.结果 分离自我国6所部队医院的194株多药耐药鲍氏不动杆菌以Group 1序列型为主,所古的比例高达73.7％除了Group 1序列型外,还发现了属于Group4、Group5、Group8、Group9、Group10序列型的菌株.结论 我国部队医院的流行克隆谱系与欧洲克隆谱系Ⅱ具有高度的同源性；该实验研究中未发现属于Group 2和Group3的菌株,说明在我国部队医院中还未发现存在有属于欧洲克隆谱系Ⅰ和Ⅲ的菌株. |
| 关 键 词： | 多药耐药鲍氏不动杆菌 克隆谱系 多重聚合酶链反应 基于序列分型 |
Analysis of prevalent clonal lineages of multidrug-resistant Acinetobacter baumannii strains from military hospitals in China |
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| DONG Zhe , DING Zhi-ping , XU Ya-ping , YAN Zhong-qiang , SHEN Ding-xia. Analysis of prevalent clonal lineages of multidrug-resistant Acinetobacter baumannii strains from military hospitals in China[J]. Chinese Journal of Nosocomiology, 2011, 21(24): 5118-5121 | |
| Authors: | DONG Zhe DING Zhi-ping XU Ya-ping YAN Zhong-qiang SHEN Ding-xia |
| Affiliation: | DONG Zhe,DING Zhi-ping,XU Ya-ping,YAN Zhong-qiang,SHEN Ding-xia (General Hospital of PLA,Beijing 100853,China) |
| Abstract: | OBJECTIVE To gain a insight into the prevalent clonal lineages and molecular epidemic tendency of multidrug-resistant Acinetobacter baumannii(MDRAB) strains causing nosocomial infections in military hospitals in China. METHODS Sequence-based typing and multiplex PCR were used to identify the prevalent clonal lineages of MDRAB strains from 6 Chinese military hospitals.The target genes of A.baumannii investigated in the present study were ompA,csuE and blaOXA-51-like. RESULTS In total,194 MDRAB isolates were ... |
| Keywords: | Multidrug-resistant Acinetobacter baumannii Clonal lineages Multiplex PCR Sequence-based typing |
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