| 不同配伍配比对麻黄-桂枝药对有效成分含量的影响 |
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| 引用本文： | 徐文杰,陈飞龙,谢颖,罗佳波. 不同配伍配比对麻黄-桂枝药对有效成分含量的影响[J]. 中国实验方剂学杂志, 2012, 18(10): 84-88 |
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| 作者姓名： | 徐文杰 陈飞龙 谢颖 罗佳波 |
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| 作者单位： | 南方医科大学中医药学院广东省中药制剂重点实验室,广州,510515 |
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| 基金项目： | 国家自然科学基金项目(81030066) |
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| 摘 要： | 目的:研究麻黄-桂枝不同比例配伍前后水煎液中有效成分含量的变化,探讨两药的配伍规律.方法:采用GCMS测定水煎液中盐酸去甲基伪麻黄碱(NMP)、盐酸去甲基麻黄碱(NME)、盐酸麻黄碱(E)、盐酸伪麻黄碱(PE)、盐酸甲基麻黄碱(ME)的煎出量；采用HPLC测定水煎液中香豆素、桂皮醇和桂皮醛的煎出量.结果:与单煎液相比,麻黄与桂枝配伍后,随着配伍药材比例增大,水煎液中以上各有效成分含量均有不同程度的降低,5种麻黄生物碱含量下降幅度在15％～42％,香豆素、桂皮醇、桂皮醛的含量下降幅度在16％～57％.结论:麻黄-桂枝不同比例配伍后,对彼此有效成分的溶出有一定的抑制作用.
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| 关 键 词： | 药对 配伍 配比 麻黄-桂枝 |
| 收稿时间： | 2011-11-21 |
Content of Active Compounds in Water Extracts of Ephedra with Cinnamomi by Compatibility of Different Ratio |
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| XU Wen-jie,CHEN Fei-long,XIE Ying and LUO Jia-bo. Content of Active Compounds in Water Extracts of Ephedra with Cinnamomi by Compatibility of Different Ratio[J]. China Journal of Experimental Traditional Medical Formulae, 2012, 18(10): 84-88 |
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| Authors: | XU Wen-jie CHEN Fei-long XIE Ying LUO Jia-bo |
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| Affiliation: | Key Laboratory of Chinese Drugs Pharmaceutics of Guangdong Province, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515,Chnia;Key Laboratory of Chinese Drugs Pharmaceutics of Guangdong Province, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515,Chnia;Key Laboratory of Chinese Drugs Pharmaceutics of Guangdong Province, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515,Chnia;Key Laboratory of Chinese Drugs Pharmaceutics of Guangdong Province, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515,Chnia |
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| Abstract: | Objective: Study on the content of active compounds in water extracts of Ephedra-Cinnamomi by compatibility of different ratio and to explain the mechanism of this compatibility. Method: The content of norpseudoephedrine (NMP), norephedrine (NME), ephedrine (E), pseudoephedrine (PE) and methylephedrine (ME), which are the major active compounds of Herba Ephedra, were analyzed by gas chromatography-mass spectrometry (GC-MS). The content of coumarin, cinnamic alcohol and cinnamaldehyde, which are the major active compounds of Cortex Cinnamomi in the extracts were analyzed by high performance liquid chromatography (HPLC). Result: The content of NMP, NME, E, PE, ME, coumarin, cinnamic alcohol and cinnamaldehyde in water extracts of pairmedicine Ephedra-Cinnamomi was lower than that of single decoction. Conclusion: Combined Ephedra with Cinnamomi, the dissolution of chemical compounds was inhibited with each other in water extracts. |
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| Keywords: | pairmedicine compatability different ratio Ephedra-Cinnamomi |
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