2010-2013年深圳市罗湖区育龄期妇女风疹IgG抗体水平及发病情况

目的 结合罗湖区女性风疹发病情况,重点研究育龄期妇女风疹发病情况及风疹血清IgG抗体水平,为控制风疹疫情,完善风疹免疫策略,预防先天性风疹综合征( CRS) 提供科学依据。方法 在罗湖区体检中心随机抽取四家体检单位,筛选18—35岁育龄期妇女,采集血清标本共164份,用酶联免疫吸附法检查血清风疹IgG抗体,同时分析罗湖区2010-2013年女性风疹发病情况。结果应涵盖所有的结果 育龄期妇女风疹IgG抗体几何平均浓度和阳性率分别为103.1626 IU/mL 和93.3%,各年龄组统计分析 ,差异无统计学意义( χ² =2.7668,P =0．2507;F=1.00,P=0.905)全文类似描述,如此排序,且随年龄增长,风疹抗体水平有所增加;本市和外市的育龄期妇女风疹IgG 抗体阳性率间的差异无统计学意义( χ² = 0．0238,P =0．8774) ,本市和外市的育龄期妇女风疹抗体平均浓度间的差异有统计学意义(F=0.207,P=0.991) ;有接种史、无接种史和接种史不详的育龄期妇女风疹IgG抗体阳性率间的差异无统计学意义( χ² = 2．0691,P =0．3554,F=1.508,P=0.224)。2010—2013年罗湖区女性风疹发病年龄主要集中在15—35岁,占女性发病人数的74.84%,2010—2013年所占比例分别为75%、75.63%、75%、64.7%。结论 对育龄期妇女加强接种风疹疫苗( 或含有风疹疫苗的联合疫苗) ,提高育龄妇女风疹抗体水平,是控制小月龄发病和先天性风疹综合征的重要手段。

Survey on the rubella-IgG antibody levels and the prevalence among women at childbearing age in Luohu District,Shenzhen City in 2010-2013

Objective To explore the prevalence of rubella and the rubella-IgG antibody levels among women of childbearing age based on the epidemiological characteristics of rubella among women in Luohu District,Shenzhen City,and to provide a scientific basis for reducing the incidence of rubella,improving the rubella immunization strategy and preventing congenital rubella syndrome（ CRS）. Methods In 2013,we randomly selected childbearing age women aged 18-35 years from 4 physical examination centers in Luohu District,and 164 serum specimens were collected to detect the rubella-IgG antibody levels by ELISA method. The prevalence of rubella was simultaneously analyzed. Results In 2013,the geometric mean concentration and the positive rate of rubella-IgG antibody in the childbearing age women in Luohu District were 103. 1626 IU /ml and 93. 3%,respectively. Neither was statistically different among various age groups（ F = 1. 00,P = 0. 905; χ2= 2. 7668,P = 0. 2507） or between local childbearing age women and migrant ones（ F = 0. 207,P = 0. 991; χ2= 0. 0238,P = 0. 8774）. Meanwhile,no statistically significant differences were found in the positive rate and geometric mean concentration of rubella-IgG antibody among childbearing age women with clear or unknown immunization history and without vaccination history（ χ2= 2. 0691,P = 0. 3554; F = 1. 508,P = 0.224）. The onset age of rubella among the women in Luohu District during 2010-2013 mainly focused between 15 and 35 years old,accounting for 74. 84% of the total female cases,and the proportions in 2010-2013 were 75%,75. 63%,75% and 64.7%,respectively. Conclusions Strengthening rubella vaccine（ or the combined MMR vaccine） inoculation before pregnancy in childbearing age women and increasing their antibody levels are the key measures for preventing the infection in the first trimester of pregnancy and CRS.