靖西县全人群麻疹抗体水平抽样调查分析

目的评估人群麻疹免疫状况,为加速控制和消除麻疹提供科学依据。方法按系统抽样和分层随机抽样方法在万吉、庞凌、峒平、罗隆、大利、甘荷、那坡、上坝、上敏等9个行政村抽取0~、6~、11~、16~、21~、26~、31~、36~、41~、46~、51~、56~60岁和18~35岁育龄妇女等13个年龄组,每个年龄组各50人,共计650名进行调查,采静脉血,用ELISA法检测麻疹IgG抗体。结果共调查675人,麻疹抗体阳性594人,阳性率为88.00%,抗体滴度几何平均数(GMT)为1:413,不同地区麻疹抗体阳性率差异有统计学意义(χ2=30.067,P=0.002),不同年龄组(含育龄妇女组)和不同性别麻疹抗体阳性率差异无统计学意义(χ2=14.621,P=0.263;χ2=0.002,P=0.962)。结论靖西县人群麻疹抗体阳性率水平比较高,形成一定的免疫屏障,但是,地区间抗体水平存在差异,需加强全县免疫规划薄弱地区的甄别和管理,积极开展薄弱地区麻疹疫苗的查漏补种和强化免疫工作。

Sampling Survey on the antibody levels of measles among the residents in Jingxi County

Objective To evaluate the immune status against measles in population so as to provide a scientific basis for speeding up measles control and elimination. Methods Based on the systematic sampling and stratified random sampling methods,650 residents selected from Wanji,Pangling,Dongping,Luolong,Dali,Ganhe,Napo,Shangba and Shangmin administrative villages were divided into the age groups of 0-,6-,11-,16-,21-,26-,31-,36-,41-,46-,51-and 56-60 years and the childbearing age group of 18-35 years（ each n = 50）. Venous blood samples were taken from all residents surveyed to detect human immunoglobulin G（ IgG） antibody to measles by ELISA method. Results A total of 675 residents were surveyed and 594 were found to be positive for measles antibody,with the positive rate of 88. 00%. The antibody geometric mean titer（ GMT） was 1：413. There were statistically significant differences in the positive rate of measles virus to antibody among different areas（ χ2= 30. 067,P〈0. 002）,but no statistically significant difference was found among different age groups（ including the childbearing age group）（ χ2= 14. 621,P = 0. 263） and among different genders（ χ2= 0. 002,P = 0. 962）. Conclusions The positive rate of measles antibody among population in Jingxi County is higher,which forms a certain immune barrier,but there exist differences in the antibody levels among different areas. It is necessary to strengthen the screening and management of immunization program and timely implement the vaccination and boosting in the weak areas of the county.