| 妇科肿瘤疫苗的研究进展 |
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| 引用本文： | Xu BL,Li Y,Cui H. 妇科肿瘤疫苗的研究进展[J]. 中国医学科学院学报, 2003, 25(4): 487-491 |
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| 作者姓名： | Xu BL Li Y Cui H |
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| 作者单位： | 1. Department of Obstetrics and Gynecology, Hangu Hospital, Tianjin
2. 北京大学,人民医院妇科肿瘤中心,北京,100044 |
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| 摘 要： | 肿瘤疫苗是妇科恶性肿瘤免疫治疗研究的热点之一。卵巢癌疫苗均为治疗性疫苗,主要包括克隆抗原疫苗、肿瘤细胞疫苗、基因工程肿瘤细胞疫苗、树突状细胞疫苗、抗独特型疫苗。子宫颈癌疫苗包括以人乳头瘤病毒为基础的多肽疫苗、载体疫苗、融合蛋白疫苗和嵌合疫苗及树突状细胞疫苗等治疗性疫苗和人乳头瘤病毒预防性疫苗。而子宫内膜癌疫苗报道很少。
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| 关 键 词： | 妇科肿瘤 肿瘤疫苗 |
| 修稿时间： | 2003-07-14 |
Development of tumor vaccine on gynecologic cancer |
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| Xu Bo-lan,Li Yi,Cui Heng. Development of tumor vaccine on gynecologic cancer[J]. Acta Academiae Medicinae Sinicae, 2003, 25(4): 487-491 |
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| Authors: | Xu Bo-lan Li Yi Cui Heng |
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| Affiliation: | Gynecologic Oncology Center, People's Hospital, Peking University, Beijing 100044, China. |
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| Abstract: | The study of tumor vaccine is one of the focus of immunological therapy on malignant gynecologic cancer.All of the ovarian carcinoma vaccine are therapeutic,including cloned antigen vaccine,tumor cell vaccine,genetic engineering tumor cell vaccine,dendritic cell(DC)vaccine,as well as anti-idiotypic vaccine.The therapeutic vaccines based on human papillomavirus(HPV)of cervical cancer are mostly summarized,including polypeptides vaccine,carrier vaccine,fusion protein or chimeric vaccine,and DC vaccine.The preventive vaccine based on HPV of cervical cancer are briefly introduced.As there are only a few reports on endometrial carcinoma vaccine. |
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| Keywords: | gynecologic cancer tumor vaccine |
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