CD147、MMP-9和VEGF在垂体瘤中的表达及与其生物学行为的关系

目的探讨CD147、MMP-9和VEGF在垂体腺瘤中的表达及其与垂体腺瘤侵袭性的相关性。方法应用免疫组化SP法对50例垂体腺瘤标本的CD147、MMP-9及VEGF表达进行检测，分析其表达与垂体腺瘤侵袭性的关系及其三者间的相关性。结果CD147在侵袭性垂体腺瘤中的强阳性及总阳性表达率分别为51.7%和93.1%，明显高于非侵袭性垂体腺瘤中的23.8%和52.4%（P＜0.05）；MMP-9在侵袭性垂体腺瘤中的强阳性及总阳性表达率分别58.6%和86.2%，明显高于非侵袭性垂体腺瘤中的14.3%和42.9%（P＜0.05）；VEGF在侵袭性垂体腺瘤中的强阳性及总阳性表达率分别为62.1%和96.6%，明显高于非侵袭性垂体腺瘤19.1%和57.1%（P＜0.05）；侵袭性垂体腺瘤组中的CD147、MMP 9和VEGF表达两两呈正相关（P＜0.05）,非侵袭性垂体腺瘤组中CD147、MMP-9和VEGF表达无明显相关性。结论CD147、MMP-9及VEGF的高表达与垂体腺瘤的侵袭性密切相关，可作为判断垂体腺瘤侵袭性生长的有效指标；在肿瘤侵袭生长过程中，CD147与MMP-9、VEGF的产生有关，VEGF与MMP-9可能存在协同作用，共同促进垂体腺瘤侵袭性生长。

Expressions of CD147, MMP-9 and VEGF in pituitary adenomas and relationship with biological behavior

Objective To explore the protein expressions of CD147,MMP-9 and VEGF in pituitary adenomas and to study the biological relationships between CD147,MMP-9,and VEGF and the invasiveness of pituitary adenomas.Methods The expressions of CD147,MMP-9 and VEGF in 50 cases were determined by the immunohistochemical SP method.Correlation among CD147,MMP-9 and VEGF,and correlation between the expressions of CD147,MMP-9 and VEGF and invasiveness of pituitary adenomas were studied.Results The intense expression and total expression rates of CD147 of pituitary adenoma patients with invasion were significantly higher than those without invasion(51.7% vs 23.8% and 93.1% vs 52.4%,P<0.05).The intense expression and total expression rates of MMP-9 in pituitary adenoma patients with invasion were significantly higher than those without invasion(58.6% vs 14.3% and 86.2% vs 42.9%,P<0.05).Also the intense expression and total expression rates of VEGF in pituitary adenoma patients were significantly higher than those without invasion(62.1% vs 19.1% and 96.6% vs 57.1%,P<0.05).There were mutually positive correlations among CD147,MMP-9 and VEGF expressions in invasive pituitary adenomas.Conclusion The high expression of CD147,MMP-9 and VEGF might relate to the aggressiveness and invasion in pituitary adenomas and may be useful markers for predicting invasiveness.In the process of invasive growth,CD147 has some relation to MMP-9 and VEGF,and MMP-9 and VEGF may act together.