Assessment of urinary protein excretion in the adolescent: effect of body position and exercise |
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| Authors: | M T Houser M F Jahn A Kobayashi J Walburn |
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| Affiliation: | 3. Schroeder Institute for Tobacco Research and Policy Studies, Truth Initiative, Washington, DC 20001, USA;4. People Designs, Durham, NC 27705, USA;5. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA;6. Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC 20007, USA;1. Department of Otorhinolaryngology, Head & Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan;2. Electron Microscopy Research Center, Mie University Graduate School of Medicine, Tsu, Japan;3. Department of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan;4. Department of Drug Discovery for Lung Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan;5. Department of Central Laboratories, Mie University Hospital, Tsu, Mie, Japan;6. Department of Genomic Medicine, Mie University Hospital, Tsu, Japan |
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| Abstract: | We examined the effects of body position and exercise on the random urinary protein/creatinine ratio (Up/Ucr) in healthy adolescents, to provide reference data to be used in a simplified evaluation of proteinuria. Random urine samples were obtained during recumbency and after both ambulation and exercise in 116 subjects. The Up/Ucr was significantly (P less than 0.0001) higher with increasing levels of activity, and was widely variable, especially during the upright and postexercise periods. No sex-related differences in Up/Ucr were noted, except during recumbency, when values were significantly (P less than 0.001) higher in females. The urinary dipstick was found to be less sensitive as a tool to define abnormal degrees of recumbent proteinuria. We conclude that body position and exercise have significant effects on protein excretion, and suggest that the Up/Ucr in recumbent and upright urine samples will be useful in the evaluation of proteinuria. |
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