| TGF-β1在氟中毒大鼠切牙牙髓中的表达 |
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| 引用本文： | 吴煜,何克新,杨亦萍,曹阳,梁志锋.TGF-β1在氟中毒大鼠切牙牙髓中的表达[J].上海口腔医学,2006,15(2):190-193. |
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| 作者姓名： | 吴煜 何克新 杨亦萍 曹阳 梁志锋 |
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| 作者单位： | 1. 广西医科大学口腔医院,儿科,广西,南宁,530021
2. 广西医科大学,生理学教研室,广西,南宁,530021 |
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| 基金项目： | 广西教育厅面上项目;广西大型仪器协作共用网测试基金 |
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| 摘 要： | 目的:研究过量氟对大鼠牙髓细胞TGF-β1表达的影响。方法:20只Wister大鼠,随机分为对照组和实验组。对照组用等量蒸馏水灌胃,实验组以20mg.kg-1.d-1氟化钠水灌胃。8周后处死动物,利用磨片、HE染色、免疫组化染色技术观察过量氟对大鼠切牙形态及TGF-β1表达的影响。采用SPSS10.0软件对数据进行t检验。结果:实验组大鼠切牙釉质牙本质生长线明显,球间牙本质增多,牙髓细胞及髓腔内侧牙本质TGF-β1表达显著弱于对照组,差异有显著性(P<0.01)。结论:过量氟可抑制牙髓细胞表达TGF-β1,影响牙体硬组织的结构。
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| 关 键 词： | 氟 牙髓细胞 大鼠 转化生长因子 |
| 文章编号： | 1006-7248(2006)02-0190-04 |
| 修稿时间： | 2005年11月5日 |
The effect of overdose fluoride on the expression of TGF-β1 in rat's dental pulps |
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| WU Yu,HE Ke-xing,YANG Yi-ping,CAO Yang,LIANG Zhi-feng.The effect of overdose fluoride on the expression of TGF-β1 in rat''''s dental pulps[J].Shanghai Journal of Stomatology,2006,15(2):190-193. |
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| Authors: | WU Yu HE Ke-xing YANG Yi-ping CAO Yang LIANG Zhi-feng |
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| Institution: | School of Stomatology, Guangxi Medical University, Nanning 530021, Jiangsu Province, China. tongtong419@163.com |
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| Abstract: | PURPOSE: To observe the effect of overdose fluoride on the expression of TGF-beta1 in rat's dental pulps. METHODS: 20 wister rats were divided into two groups. In the control group, equal dose distilled water were given to the rats. In the experimental group, 20 mg.kg(-1).d(-1) NaF were given. After 8 weeks of treatment, immunohistochemical staining was adopted for detection of the expression of TGF-beta1 in dental pulps of the rats. SPSS10.0 software package was used for Student's t test. RESULTS: Image analysis results showed that the expression of TGF-beta1 in the dental pulp and inner dentin were inhibited in the experimental group as compared with the control group (P<0.01). CONCLUSION: The overdose fluoride will inhibit the secretion of TGF-beta1, which leads to abnormal development of the teeth. |
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| Keywords: | Fluoride Dental pulp Rat Transforming growth factor |
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