Effect of seleptine on retrieval of active avoidance task in rats |
| |
Authors: | N. B. Pankova E. V. Nikushkin G. S. Chernov |
| |
Affiliation: | (1) Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow |
| |
Abstract: | We have examined seleptine, a new derivative of the atypical neuroleptic clozapinum, on the retrieval of the active avoidance task in rats placed in a shuttlebox. Retention of the conditioned response was assessed in the test of repeated training for the same task to the score achieved in the first session. After oral seleptine (100 mg/kg), the retention of the active avoidance task was deteriorated to a greater extent than the ability for a new learning. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 7, pp. 28–30, July, 1998 |
| |
Keywords: | seleptine neuroleptics avoidance response |
本文献已被 SpringerLink 等数据库收录! |
|