Cytostatic therapy and blood antioxidants/prooxidants balance in acute myeloblastic leukemia patients |
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Authors: | Daniela I Gerova Vladimir T Gerov Tatyana M Yankova Liana T Gercheva Diana G Ivanova |
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Institution: | (1) Department of Preclinical, Clinical Pharmacology and Biochemistry, University of Medicine, Varna, Bulgaria;(2) Department of Internal Medicine, Clinics of Hematology, University of Medicine, Varna, Bulgaria |
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Abstract: | To analyze the effects of conventional polychemotherapy of acute myeloblastic leukemia (AML) patients on the prooxidants/antioxidants
balance in plasma total antioxidant status (TAS) and a single plasma antioxidant — uric acid (UA) were measured. Lipid peroxidation
was assessed by malonedialdehyde (MDA) content. Total serum iron was monitored as a potential source of nontransferrin-bound
iron with a role in initiation of oxidative burst. A group of patients in the acute phase of AML (group A) and a group of
patients in complete remission of AML (group B) were studied. A strong correlation between UA values and TAS (r = 0.8 for
group A, r = 0.9 for group B) was revealed in the course of the treatment. Strong negative correlation (r = −0.9) between
TAS and MDA was shown for both groups. Total iron significantly increased in the course of chemotherapy. We have established
that polychemotherapy leads to the consumption of antioxidants and increased lipid peroxidation in AML patients. An appropriate
supplementation with antioxidants at the end of the polychemotherapy treatment could be considered. |
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Keywords: | Acute myeloblastic leukemia total antioxidant status uric acid lipid peroxidation total serum iron |
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