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| 影响葛根总黄酮生物粘附片体外释放度的因素研究 | |
| 引用本文： | 向大雄,李焕德,罗杰英,袁红波,张杰,孙银香.影响葛根总黄酮生物粘附片体外释放度的因素研究[J].中国药房,2004,15(8):465-467. |
| 作者姓名： | 向大雄 李焕德 罗杰英 袁红波 张杰 孙银香 |
| 作者单位： | 1. 中南大学湘雅二医院临床药学研究室,长沙市,410011 2. 湖南中医学院,长沙市,410007 3. 中南大学湘雅三医院药剂科,长沙市,410013 |
| 摘 要： | 目的 :探讨影响葛根总黄酮生物粘附片释放度的主要因素。方法 :以羟丙基甲基纤维素 (HPMC)与卡波姆 (CP)为生物粘附材料和骨架材料、乳糖为致孔剂制备葛根总黄酮生物粘附片 ;采用转篮法测定释放度 ,以0 1mol/LHCl为溶出介质 ,转速为100r/min ,测定累积释放度 ,同时考察HPMC用量、CP用量、致孔剂种类、乳糖用量、压片颗粒大小、介质 pH等因素对释放度的影响。结果与结论 :HPMC用量、CP用量、致孔剂种类、乳糖用量、压片时颗粒大小、介质 pH等因素对生物粘附片溶出均有明显影响 |
| 关 键 词： | 葛根总黄酮 生物粘附片 释放度 影响因素 |
| 文章编号： | 1001-0408(2004)08-0465-03 |
| 修稿时间： | 2003年8月25日 |
Experimental Study on the Factors Affecting in Vitro Dissolubility of Total Puerariae Flavones Bioadhesive Tablets |
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| XIANG Daxiong,LI Huande,YUAN Hongbo,SUN Yinxiang.Experimental Study on the Factors Affecting in Vitro Dissolubility of Total Puerariae Flavones Bioadhesive Tablets[J].China Pharmacy,2004,15(8):465-467. | |
| Authors: | XIANG Daxiong LI Huande YUAN Hongbo SUN Yinxiang |
| Abstract: | OBJECTIVE:To study the main factors affecting in vitro dissolubility of total puerariae flavones(TPF)bioadˉhesive tablets.METHODS:Using HPMC,Carbopol(CP934NP)as bioadhesive and base materials,lactose as porogenic agent to prepare bioadhesive tablets;Basket-rotating method was adopted to determine the dissolubility while0.1mol/L HCl was used as dissolution medium,Rotational speed was100r/min.The accumulated dissolution was detected and the influence of the amount of HPMC,CP,kind of porogenic agent,amount of lactose,size of granules in pressed tablets and medium pH on dissolubility was observed.RESULTS&CONCLUSION:The amount of HPMC,CP and lactose,kind of porogenic agent,size of granules in tablets and medium pH can affect the dissolubility of bioadhesive tablets. |
| Keywords: | total puerariae flavones bioadhesive tablet dissolubility affecting factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |