经直肠给予米索前列醇预防产后出血的临床观察

目的 :探讨经直肠给予米索前列醇预防产后出血的效果。方法 :足月妊娠阴道分娩产妇 2 0 0例 ,随机分成米索前列醇组(于胎儿娩出后立即直肠给予米索前列醇 4 0 0 μg)和催产素组 (于胎儿娩出后立即肌注催产素 2 0u) ,每组各 10 0例。观察两组第三产程时间 ,产后 2h、2 4h出血量 ,发生产后出血病例数及药物不良反应和血压变化情况。结果 :两组第三产程时间无显著性差异 (P >0 .0 5 ) ,产后 2h、2 4h出血量在米索前列醇组明显少于催产素组 ,有极显著差异 (P <0 .0 1) ,米索前列醇组未发生产后出血病例。两组用药后均无明显不良反应及血压改变。结论 :经直肠给予米索前列醇预防产后出血效果显著 ,方法简便、安全。

Clinical Evaluation of Preventing Postpartum Hemorrhage by Putting Miso prostol in Rectum

Objective: To study the effect on the prevention of postpartum bleeding by putting misoprostol in rectum. Methods: 200 women with bleeding of the uterus for vagina birth were prospectively studied at random on 100 cases with misoprostol and 100 cases with oxytocin. Results: There was no statistical difference between the two groups( P >0.05)about the time in third page of birth. The misoprostol groups who's bleeding guantity of the uterus after birth two and twenty-four hours is less than the oxytocin groups one. And the difference between the two groups was statistically significant( P <0.01).There were no side effects and the changes of blood pressure between the two groups. Conclusion: It is a safe and effective method to prevent prospartum hemorrhage by putting misoprostol in rectum.