类固醇激素鼓室给药治疗内耳疾病的基础与临床

近年来鼓室用药治疗内耳疾病技术得到了飞速发展,该方法保留了完整的内耳结构、安全性较高,是目前针对内耳局部的主要给药方式。鼓室用药优于胃肠或静脉给药,可避开血-迷路屏障直接进入内耳使得内、外淋巴液中的药物浓度较高;同时避免了全身用药的不良反应。在临床实践中,经鼓室应用类固醇激素治疗内耳疾病取得了良好的效果。文章阐述了近年来类固醇激素鼓室内给药治疗内耳疾病的基础与临床方面的进展。

Preclinical and Clinical Study of Steroid Hormone in Treating Inner Ear Disease by Intratympanic Administration

In recent years,the technology of treating internal ear disease by intratympanic administration has been developed rapidly.The method keeps the integrated structure of internal ear with high safety,which is now the main local treatment for inner ear diseases.Intratympanic administration is better than that by stomach intestine or vessel,which can result in high accumulated concentration in endolympha and perilympha by directly entrying inner ear and get out of the way of blood-labyrinth barrier.At the same ...