支气管肺发育不良患儿肺功能变化的动态随访研究

目的监测支气管肺发育不良(bronchopulmonary dysplasia,BPD)生后3年内潮气呼吸肺功能动态变化,以探讨BPD对患儿远期肺功能的影响。方法收集BPD患儿生后3年内临床资料及肺功能结果,与同龄非BPD患儿对比。结果 BPD患儿生后3年内均存在肺功能异常,肺功能参数如潮气量(VT)、吸气时间(TI)、达峰时间比(TPTEF/TE)、达峰容积比(VPTEF/VE)降低,呼吸频率(RR)、呼气时间(TE)升高,与非BPD患儿比较,差异有统计学意义(P0.05);身高及体重均较同龄非BPD儿童下降(P0.05)。结论 BPD导致婴儿肺功能异常,并影响生长发育。

Clinical follow-up of pulmonary function in infants with bronchopulmonary dysplasia

Objective To investigate the changes of tidal breath pulmonary function in infants with bronchopulmonary dysplasia(BPD) for 3 years. Method BPD infants were contacted by out-patient follow-up,pulmonary function including RR,VT,TI,TE,TPTEF/TE,VPTEF/VE,body height,weight were monitored at 1,2 and 3 years old. Results There were significant differences in pulmonary function,body height and weight with BPD infants compared with non BPD infants (P<0.05),the values of VT,TI,TPTEF/TE,VPTEF/VE in BPD group were lower than those in the non-BPD group,the values of TE,RR of BPD group were higher than those in the non-BPD group (P<0.05). Conclusion BPD infants have damaged pulmonary function and retardation of growth before 3 years old.