5-benzylidene pyrrolones. IV--Synthesis and antifungal activity of some 5-benzylidene derivatives of 1,2-dimethyl-3-carbethoxy-pyrrol-4-one

In order to investigate the antifungal activity of pyrrolones, the synthesis of derivatives of 5-benzylidene-1,2,-dimethyl-3-carbethoxy-pyrrol-4-one was achieved by a one-step reaction. The condensation reaction was applied to the above-mentioned heterocycle and seven substituted benzaldehydes were obtained providing the entitled compounds, of which six are original. They have preferential E configuration. Antifugal data against Neurospora crassa in comparison with ketoconazole showed that many of the compounds exhibit interesting antifungal activity.