亚临床甲状腺功能减退合并妊娠的研究进展

妊娠期甲状腺激素的合成、分泌、代谢和调节发生相应的改变,目前促甲状腺激素(TSH)仍作为诊断妊娠期甲状腺疾病首选的指标。现在的观点认为妊娠妇女发生亚临床甲状腺功能减退症(简称亚临床甲减)导致流产、早产、胎盘早剥等产科并发症的发生率增加,并可能影响后代的智力发育。对确诊亚临床甲状腺功能减退的妊娠期妇女早期即给予左旋甲状腺素治疗能降低上述并发症的发生率,但是否对所有准备怀孕妇女或确诊怀孕妇女常规进行甲状腺功能筛查仍有争议。

Research Progress of Subclinical Hypothyroidism Complicating Pregnancy

The synthesis secretion,metabolism and regulation of thyroid hormones during pregnancy change with gestational age.At present,thyrotrophic-stimulating hormone(TSH) is used as the first-line marker for diagnosis of thyroid disease in pregnancy.Subclinical hypothyroidism during pregnancy is not only associated with an increased risk of miscarriage,preterm delivery,placental abruption morbidity of pregnancy,but also has a deleterious effect of the fetal development,and an early supplementation with l-thyroxin might reduce these risks.But there is still controversies of routine screening for subclinical hypothyroidism in all the pregnant women and those contemplating pregnancy.