| 肝素雾化吸入对豚鼠凝血时间及小鼠尾出血时间的影响 |
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| 引用本文： | 王庆利,盛春元,赵桂宏.肝素雾化吸入对豚鼠凝血时间及小鼠尾出血时间的影响[J].中国药房,2001,12(2):82-83. |
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| 作者姓名： | 王庆利 盛春元 赵桂宏 |
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| 作者单位： | 1. 中国医学科学院、中国协和医科大学药物研究所,
2. 北京通州区潞河医院药剂科, |
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| 摘 要： | 目的 :研究雾化吸入低分子量肝素 (LMWH )和标准肝素 (SH)对动物凝血时间和出血时间的影响。方法 :LMWH和SH超声雾化后经简易面罩吸入 ,连用7d ,观察对豚鼠凝血时间和小鼠尾出血时间的影响。结果 :与N S组比较 ,LMWH800IU/L、400IU/L和SH800IU/L、400IU/L对豚鼠凝血时间和小鼠尾出血时间均无显著影响 (P>0.05) ;LMWH800IU/L、400IU/L和SH800IU/L、400IU/L之间也无显著性差异 (P>0.05)。结论 :LMWH和SH雾化吸入是抗哮喘治疗的一种安全的给药途径
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| 关 键 词： | 低分子量肝素 标准肝素 凝血时间 出血时间 |
| 文章编号： | 1001-0408(2001)02-0082-02 |
| 修稿时间： | 2000年8月29日 |
The Effects of Inhalation of Aerosolized Low Molecular Weight Heparin on the Clotting Time in Guinea Pigs and Bleeding Time in Mice |
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| Wang Qingli,SHENG Chunyuan,ZHAO Guihong.The Effects of Inhalation of Aerosolized Low Molecular Weight Heparin on the Clotting Time in Guinea Pigs and Bleeding Time in Mice[J].China Pharmacy,2001,12(2):82-83. |
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| Authors: | Wang Qingli SHENG Chunyuan ZHAO Guihong |
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| Abstract: | AIM:To study the effects of inhalation of aerosolized low molecular weight heparin(LMWH)and standard heparin(SH) on the clotting time and bleeding time in guinea pigs and mice.METHODS:Guinea-pigs and mice inhaled aersolized LMWH and SH for 7 days,and the clotting time in guinea-pigs and tail bleeding time in mice were observed.RESULTS:Compared with vehicle,LMWH 800IU/L,400IU/L and SH 800IU/L,400IU/L had no significant effects on the clotting time in guinea-pigs and tail bleeding time in mice(P>0.05);There were no significant differences between LMWH 800IU/L,400IU/L and SH 800IU/L,400IU/L(P>0.05).CONCLUSION:Inhalation of aerosolized LMWH and SH had no significant effects on clotting time and bleeding time in animals. |
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| Keywords: | low molecular weight heparin standerd heparin clotting time bleeding time |
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