Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats |
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| Authors: | AG Jagtap PB Patil |
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| Institution: | 1. Department of Horticulture, Faculty of Agriculture, Ferdowsi University of Mashhad, P.O. Box 91775-1163, Mashhad, Iran;2. Department of Medicinal Plants, Shahrekord Branch, Islamic Azad University, PO Box 166, Shahrekord, Iran;1. Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy;2. The BioRobotics Institute, Sant’Anna School of Advanced Studies, viale Rinaldo Piaggio 34, 56025, Pontedera, Pisa, Italy;3. Crop Research Institute, Drnovska 507, 161 06 Prague, Czech Republic;4. Department of Plant Protection, Czech University of Life Sciences Prague, Kamycka 129, 165 00, Praha 6, Suchdol, Czech Republic;5. School of Pharmacy, University of Camerino, Camerino, Italy;6. Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, 627 412, Tirunelveli, Tamil Nadu, India;1. Traditional Medicine Clinical Trail Research Center, Shahed University, Tehran, Iran;2. Oral and Maxillofacial Pathology Department, Faculty of Dentistry, Shahed University, Tehran, Iran;3. Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran;1. Department of Seafood Processing, Faculty of Marine Sciences, Tarbiat Modares University, Noor, Iran;2. Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon 25457, South Korea;3. Disease Control and Prevention Lab, Department of Animal Health and Management, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India |
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| Abstract: | Cuminum cyminum is widely used as a spice in many countries. The aim of the present study was to investigate the effect of methanolic extract of seeds of C. cyminum (CC) on diabetes, oxidative stress and formation of advanced glycated end products (AGE) and obtain comparison with glibenclamide. In vitro studies indicated that CC inhibited free radicals and AGE formation. Treatment of streptozotocin-diabetic rats with CC and glibenclamide for 28 days caused a reduction in blood glucose, glycosylated hemoglobin, creatinine, blood urea nitrogen and improved serum insulin and glycogen (liver and skeletal muscle) content when compared to diabetic control rats. Significant reduction in renal oxidative stress and AGE was observed with CC when compared to diabetic control and glibenclamide. CC and glibenclamide improved antioxidant status in kidney and pancreas of diabetic rats. Diabetic rats showed increase in rat tail tendon collagen, glycated collagen, collagen linked fluorescence and reduction in pepsin digestion. Treatment with CC significantly improved these parameters when compared to diabetic control and glibenclamide group. Though the antidiabetic effect of CC was comparable to glibenclamide it had better effect in controlling oxidative stress and inhibiting the AGE formation, which are implicated in the pathogenesis of diabetic microvascular complications. |
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