羊膜移植治疗暴露性角膜炎的临床疗效观察

目的:观察羊膜移植治疗暴露性角膜炎的临床疗效.方法:回顾性分析2015-09/2016-09在我院就诊的经外院药物治疗无效、反复发作的暴露性角膜炎患者14例19眼,采用羊膜移植术治疗,术后观察羊膜溶解时间、角膜透明度、角膜荧光染色、视力、并发症及复发情况.结果:所有患者在术后3~5 d出现羊膜溶解,7~14 d出现羊膜脱落.裂隙灯检查示11例16眼患者角膜透明度基本恢复透明,治疗前和治疗28 d后角膜透明度及角膜荧光染色评分差异均具有统计学意义(P<0.05).所有患者视力均不同程度提高,且未出现并发症.结论:羊膜移植治疗暴露性角膜炎具有良好的临床效果.

Clinical observation on amniotic membrane transplantation in exposure keratitis

AIM: To observe the effect of amniotic membrane transplantation(AMT)in exposure keratitis.

METHODS: A prospective study of 14 cases(19 eyes)with exposure keratitis were treated with AMT in our hospital from September 2015 to September 2016. The patients were resistant to various conventional medications. The time of amniotic membrane absorbed, corneal opacification, fluorescein staining, visual acuity, complications and recrudescence were observed after transplantation.

RESULTS: Amniotic membrane started to dissolve in 3-5d and fell off within 7-14d after transplantation in all patients. Slit-lamp examinations showed that the cornea turned transparent in 16 eyes. There were significant diffrrences in the scores of corneal opacification and fluorescein staining at 28d after treatment compared before treated(P<0.05). Visual acuity increased in all patients to varying degree with no complications.

CONCLUSION: AMT has a good effect in the treatment of exposure keratitis.