特发性视网膜前膜的临床分类及胶原测定

目的:通过对特发性视网膜前膜的两种胶原测定决定前膜类型.方法:对25例25眼特发性视网膜前膜依据眼底表现进行分类,包括玻璃体纸样黄斑反射膜(cellophane macular reflex membrane,CMRM)型和视网膜前黄斑纤维膜(preretinal macular fibrosis membrane,PMFM)型,并对手术获取的该25例25眼特发性视网膜前膜行免疫组织化学,测定组织中Ⅵ型及Ⅰ、Ⅱ型胶原,比较眼底检查与病理检查的符合率.结果:依据眼底表现将特发性视网膜前膜分CMRM型共10例10眼,PMFM型共15例15眼;对手术获取的标本行免疫组化结果:Ⅵ型胶原纤维为主者16例16眼,Ⅰ、Ⅱ型胶原为主者9例9眼.结论:特发性视网膜前膜类型应以病理特征为主.

Clinical classification and collagen measurement for idiopathic epiretinal membrane

·AIM: To decide the type of the idiopathic epiretinal membrane by measuring collagens. ·METHODS:Totally 25 cases (25 eyes) were divided into cellophane macular reflex membrane ( CMRM ) and preretinal macular fibrosis membrane( PMFM) by fundus manifestation. Then the specimens of peeled idiopathic epiretinal membranes were made immunohistochemistry and measured for the collagen of Ⅵ and Ⅰ and Ⅱ. The coincidence rate were tested between the fundus examination and pathological examination. ·RESULTS: The idiopathic epiretinal membranes were classified into 10 CMRM and 15 PMFM by fundus manifestation. The immunohistochemical specimens were classified into 16 Ⅵ collagens and 9Ⅰ or Ⅱ collagens. ·CONCLUSION: The pathological examination is the means of the type of the idiopathic epiretinal membranes.