| 环氧化酶-2与胃癌的相关性研究进展 |
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| 引用本文： | 汪步海,侯晓华.环氧化酶-2与胃癌的相关性研究进展[J].现代医学,2003,31(1):60-63. |
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| 作者姓名： | 汪步海 侯晓华 |
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| 作者单位： | 1. 东南大学附属扬州第一医院肿瘤科,江苏扬州,225001
2. 武汉协和医院消化内科,湖北武汉,430022 |
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| 摘 要： | 近年的研究表明，环氧化酶-2（COX-2）在胃癌中的表达增强，且可能在胃癌的发生发展过程中起了较为重要的作用。COX-2的表达与胃癌的组织来源有关。COX-2表达于肿瘤细胞的胞浆中，且其表达受启动子CPG鸟甲基化，NF-kappaB及p53突变等因素调节，幽门螺杆菌感染可以使COX-2表达增强，使用COX-2特异性抑制剂可以干预COX-2的表达，抑制细胞增殖，诱导细胞凋亡。
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| 关 键 词： | 环氧化酶－2 胃癌 相关性研究 |
| 文章编号： | 1671-7562(2003)01-0060-04 |
| 修稿时间： | 2002年7月22日 |
Progress of the related research between cyclooxygenase-2 and gastric cancer |
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| WANG Bu hai ,HOU Xiao hua.Progress of the related research between cyclooxygenase-2 and gastric cancer[J].Modern Medical JOurnal,2003,31(1):60-63. |
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| Authors: | WANG Bu hai HOU Xiao hua |
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| Institution: | WANG Bu hai 1,HOU Xiao hua 2 |
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| Abstract: | Recent reports suggest that the expression of cyclooxygenase?2 (COX?2) is strong in gastric cancer.The high expression of COX?2 may play an important role in the process of the gastric carcinogenesis.The expression of COX?2 is relevant to the histogenesis of gastric carcinoma.COX?2 is localized in the cytoplasm of gastric carcinoma cells and its expression is regulated by CPG island's methylation in promoter,NF?kappa B and p 53 mutation.The infection of Helicobacter pylori increse the expression of COX?2.We could intervene the expression of COX?2,suppress proliferation and induce apoptosis by using specific COX?2 inhibitor. |
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| Keywords: | cyclooxygenase gastric cancer gene expression |
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