κ阿片激动剂的致心律失常作用涉及百日咳毒素敏感的G蛋白机制 |
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引用本文: | 陆源,胡爱萍,单绮娴,沈岳良,夏强,黄德明.κ阿片激动剂的致心律失常作用涉及百日咳毒素敏感的G蛋白机制[J].中国药理学通报,1997(6). |
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作者姓名: | 陆源 胡爱萍 单绮娴 沈岳良 夏强 黄德明 |
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作者单位: | 浙江医科大学机能中心,香港大学医学院生理系 |
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摘 要: | 目的:探讨百日咳毒素(PTX)敏感的G蛋白是否介导κ阿片激动剂的心脏效应。方法:应用离体大鼠心脏Langendorf灌流模型观察κ阿片激动剂U50488H的心脏作用并探讨其可能机制。结果:研究结果表明,U50488H可导致心律失常、降低心率、心肌收缩力量和冠脉流量;MR2266和百日咳毒素(PTX)预处理后,可取消U50488H的致心律失常作用,但不能取消其降低心肌收缩力量和冠脉流量的作用。结论:结果提示κ阿片激动剂的致心律失常作用涉及PTX敏感的G蛋白机制。
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关 键 词: | U50488H 百日咳毒素 心律失常 |
Pertussis toxin sensitive G proteins involved in the arrhythmogenic effect of κ opioid agonist |
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Abstract: | AIM: To explore whether pertussis toxin sensitive G protein is involved in the cardiac effect of κ opioid agonist. METHODS: In the present study, the Langendorff isolated perfused rat heart was used as a model for study of cardiac effect of κ agonist and its possible mechanisms. RESULTS: It was shown that U50488 H induced arrhythmias, reduced heart rate, myocardial contractile force and coronary flow. Pretreatment with MR2266, a specific κ antagonist, and pertussis toxin, which ribosylates and inactivates the Gi like proteins, abolished the arrhythmogenic effect of U50488 H, but failed to cancel the reduction of contractile force and coronary flow induced by U50488 H. CONCLUSION: The results suggested that the arrhythmogenic effect of κ opioid agonist U50488 H on the isolated rat heart involved pertussis toxin sensitive G proteins. |
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Keywords: | U50488 H pertussis toxin arrhythmia |
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