Oral calcium loading test and response to diuretics in normal taiwanese school children |
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| Authors: | Yuan-Hao Chen An-Jen Lee Charng-Shing Lin Chiung-Hui Chen Russell W. Chesney F. Bruder Stapleton Shane Roy III |
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| Affiliation: | (1) Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, P.O. Box 90055-36, Taipei, Taiwan, Republic of China;(2) Department of Pediatrics, National Taiwan University Hospital, P.O. Box 90055-36, Taipei, Taiwan, Republic of China;(3) University of Tennessee, Memphis, Tennessee, USA;(4) State University of New York at Buffalo, New York, USA |
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| Abstract: | To investigate possible mechanisms of increased urinary calcium excretion and increased prevalence of urolithiasis in 16- to 20-year-old children, oral calcium loading and diuretic tests were performed in 120 normal children in three age groups (7–8, 12–13, and 17–18 years of age). Urinary calcium/creatinine ratios and 24-h urinary calcium excretion were significantly increased following the oral calcium loading test in 17- to 18-year-olds compared with the two younger age groups. Oral furosemide resulted in increased urinary calcium excretion in the 17- to 18-year age group, while hydrochlorothiazide was less effective in reducing urinary calcium excretion in this age group. These results suggest that increased intestinal calcium absorption and decreased renal tubular reabsorption of calcium in 17- to 18-year-olds may be contributing factors in the increased prevalence of nephrolithiasis in older Taiwanese children. |
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| Keywords: | Calcium loading Diuretics Calcium excretion |
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