系统性红斑狼疮辨证分型与可溶性粘附分子之间关系探讨

目的]探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)辨证分型的实质,寻求SLE辨证分型的实验依据。方法]采用酶联免疫吸附法(ELISA法)测定SLE患者中肝肾阴虚型、热毒炽盛型的可溶性细胞间粘附分子-1(solubleintercellular adhesion molecule-1,sICAM-1)、可溶性血管细胞粘附分子-1(soluble vascular cell adhesion molecule-1,sVCAM-1)血清水平的变化,并与正常对照组比较;分析不同证型两指标之间及其与C反应蛋白(CRP)、补体3(C3)、补体4(C4)含量的相关性。结果]肝肾阴虚型和热毒炽盛型的SLE患者血清sICAM-1、sVCAM-1含量高于正常对照组(P<0.01),且热毒炽盛型的血清sVCAM-1含量高于肝肾阴虚型(P<0.05);SLE患者的sICAM-1与sVCAM-1有较好的相关性。结论]血清sICAM-1与sVCAM-1含量测定对SLE的诊断和辨证有一定参考价值。

Relationship Between Syndrome Patterns of Systemic Lupus Erythematosus and Soluble Adhesion Molecules

Objective ] To investigate the decisive factor of syndrome differentiation of systemic lupus erythematosus (SLE) , so as to provide its experimental evidence. Methods] Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in SLE patients with yin deficiency of the liver and kidney (group B) and with excessive toxic heat (group C) were detected by enzyme-linked immunosorbent assay (ELISA) . Serum levels of sICAM-1 and sVCAM-1 in SLE patients were compared with those in healthy volunteers (group A). Relationship of serum C-reaction protein (CRP), complement 3 ( C3) and complement 4 (C4) with sICAM-1 and sVCAM-1 as well as relationship between sICAM-1 and sVCAM-1 in SLE patients were observed. Results ] Serum levels of sICAM-1 and sVCAM-1 in groups B and C were higher than those of group A ( P < 0.01) and the level of sVCAM-1 in group C was higher than that of group B ( P < 0.05) . A certain relationship existed between serum levels of sICAM-1 and sVCAM-1 in SLE patients. Conclusion] The determination of serum sICAM-1 and sVCAM-1 will supply evidence for the diagnosis and syndrome differentiation of SLE.