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十一酸睾酮治疗老年男性更年期综合征的临床观察
引用本文:冯德辉,杨彬.十一酸睾酮治疗老年男性更年期综合征的临床观察[J].疑难病杂志,2004,3(1):18-19.
作者姓名:冯德辉  杨彬
作者单位:524001,湛江,广东医学院附属医院老年病科
摘    要:目的 探讨十一酸睾酮治疗老年男性更年期综合征的疗效。方法  5 8例诊断为老年男性更年期综合征患者随机分为 2组 ,观察组 34例给予口服十一酸睾酮 4 0mg,3次 d ,疗程 4周 ;对照组 2 4例给予口服安慰剂治疗。观察治疗后 2组的临床症状、血睾酮水平及抑郁症状评分变化并进行比较。结果 治疗后观察组及对照组症状均有改善 ,但观察组改善更为明显 ,2组比较有非常显著性差异 (P<0 .0 1) ;观察组血睾酮水平治疗后 (2 5 6 .13μg dl± 2 0 .78μg dl)较治疗前 (132 .4 1μg dl± 18.5 1μg dl)有显著提高 (P <0 .0 1) ,2组治疗后比较 ,有非常显著性差异 (P <0 .0 1) ;观察组治疗后抑郁症状评分各指标亦有明显改善 ,与对照组比较有显著性差异 (P <0 .0 5 )。结论 十一酸睾酮是治疗老年男性更年期综合征的一种有效、安全的雄激素补充疗法。

关 键 词:十一酸睾酮  老年人  男性更年期综合征
文章编号:1671-6450(2004)01-0018-02
修稿时间:2003年11月13

Clinical observation on testosterone undecanoate in treating climacteric syndrome in senile men
FENG Dehui,YANG Bin.Clinical observation on testosterone undecanoate in treating climacteric syndrome in senile men[J].Journal of Difficult and Complicated Cases,2004,3(1):18-19.
Authors:FENG Dehui  YANG Bin
Institution:FENG Dehui,YANG Bin. Department of Geriatrics,Affiliated Hospital of Guangdong Medical College,Guangdong,Zhanjiang 524001,China
Abstract:Objective To observe the therapeutic effect of testosterone undecanoate on climacteric syndrome in senile men.Methods 58 senile male patients with climacteric syndrome were randomly divided into two groups. 34 patients in observation group were treated by testosterone undecanoate 40mg once for oral administration, 3 times a day;24 patients in control group were treated by placebo taken orally, with a treatment course of 4 weeks for both groups. The clinical symptoms, blood testosterone levels and subjective depression state were evaluated before and after treatment in both groups.Results The clinical symptoms in both groups were improved, however those in observation group were more obvious, there was a significant difference between two groups (P<0.01). The blood testosterone levels in observation group after treatment (256.13 μg/dl±20.78 μg/dl) were significantly higher than those before treatment (132.41 μg/dl±18.51 μg/dl,P<0.01).There was a significant difference in blood testosterone levels after treatment between two groups (P<0.01).The parameters of depression score in observation group were significantly improved, as compared with those in control group (P<0.05).Conclusion Testosterone undecanoate is an effective and safe supplementary therapy for climacteric syndrome in aged men.
Keywords:Testosterone undecanoate  The aged  Climacteric syndrome in aged men
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