| 单纯及合并冠心病2型糖尿病患者血清对氧磷酯酶-1活性及丙二醛水平测定 |
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| 引用本文： | 张苏河,李鹏诺,付艳芹,李青菊,栗夏莲,田晨光,张东铭,陈璐璐.单纯及合并冠心病2型糖尿病患者血清对氧磷酯酶-1活性及丙二醛水平测定[J].郑州大学学报(医学版),2006,41(2):295-297. |
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| 作者姓名： | 张苏河 李鹏诺 付艳芹 李青菊 栗夏莲 田晨光 张东铭 陈璐璐 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院内分泌科,武汉,430022;郑州大学第二附属医院内分泌科,郑州,450014;郑州大学第二附属医院内分泌科,郑州,450014;郑州大学第一附属医院内分泌科,郑州,450052;华中科技大学同济医学院附属协和医院内分泌科,武汉,430022 |
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| 摘 要： | 目的:测定2型糖尿病并发冠心病患者对氧磷酯酶-1(PON1)活性和丙二醛水平.方法:分别采用紫外分光光度法和比色法测定正常对照组(NC组,n=40)、单纯糖尿病组(DM组,n=47)及糖尿病并发冠心病组(DMCHD组,n=43)血清PON1活性及丙二醛(MDA)水平,计算并测定体质量指数(BMI)及血脂水平.结果:3组间比较,血脂水平差异无统计学意义(P＞0.05);与NC组、DM组比较,DMCHD组BMI增大(P均＜0.05).DM组及DMCHD组PON1活性均低于NC组,MDA水平均高于NC组(P均＜0.05),DMCHD组PON1活性低于DM组,MDA水平高于DM组(P均＜0.05).且PON1活性与MDA水平呈负相关(r=-0.544,P＜0.01).结论:血清PON1活性降低和MDA水平升高是糖尿病并发冠心病的独立危险因素.
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| 关 键 词： | 对氧磷酯酶-1 脂质过氧化 2型糖尿病 冠心病 |
| 收稿时间： | 2005-01-21 |
| 修稿时间： | 2005年1月21日 |
Detection of serum paraoxonase1 activity and MDA level in type 2 diabetes mellitus and complicated by coronary heart disease patients |
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| ZHANG Suhe,LI Pengnuo,FU Yanqin,LI Qingju,LI Xialian,TIAN Chenguang,ZHANG Dongming,CHEN Lulu.Detection of serum paraoxonase1 activity and MDA level in type 2 diabetes mellitus and complicated by coronary heart disease patients[J].Journal of Zhengzhou University: Med Sci,2006,41(2):295-297. |
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| Authors: | ZHANG Suhe LI Pengnuo FU Yanqin LI Qingju LI Xialian TIAN Chenguang ZHANG Dongming CHEN Lulu |
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| Institution: | 1 . Department of Endocrinology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022; 2 . Department of Endocrinology, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014 ;3.Department of Endocrinology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 |
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| Abstract: | Aim: To detect the paraoxonase(PON1) activity and MDA level in DM with coronary heart disease(DMCHD) patients. Methods: PON1 activity and MDA level were determined with spectrophotography and colorimetric method in DM patients(n=47), DMCHD patients(n=43) and control subjects(n=40).BMI and serum TC,TG,HDL,LDL levels were detected.Results:There were no differences of TC,TG,HDL,and LDL levels among 3 groups (P>0.05). Compared with control and DM groups,BMI of DMCHD group increased significantly (P<0.05). PON1 activity of DM group and DMCHD group was lower than that of control group(P<0.05). PON1 activity of DMCHD group was lower than that of DM group(P<0.05). MDA level of DM group and DMCHD group was higher than that of control group (P<0.05).MDA level of DMCHD group was higher than that of DM group (P<0.05).PON1 activity was negatively correlated with MDA level (r=-0.544, P<0.01).Conclusion:The decreased serum PON1 activity and increased MDA level are independent risk factors of DMCHD. |
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| Keywords: | paraoxonase1 lipid peroxidation type 2 diabetes mellitus coronary heart disease |
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