急性中毒患者血清可溶性白细胞介素2受体检测的临床意义

目的 探讨血清可溶性白细胞介素2受体(sIL-2R)在急性中毒中的临床意义。方法采用 ELISA 法检测80例急性中毒患者(镇静催眠药、乙醇、一氧化碳及农业杀虫剂各20例)及20例正常人血清 sIL-2R。结果 急性乙醇中毒组(AL 组)与急性一氧化碳组(CO 组)血清 sIL-2R 均高于正常对照组(P<0.01),急性镇静催眠药中毒组(SH 组)、急性农业杀虫剂中毒组(FI 组)与对照组比较差异无显著性(P>0.05);AL 组与 CO 组血清 sIL-2R 均高于 SH 组(P<0.05),余各中毒组间差异无显著性(P>0.05);AL 组治疗后 sIL-2R 低于治疗前(P<0.05),CO 组治疗后 sIL-2R明显低于治疗前(P<0.01),SH 组与 FI 组治疗后 sIL-2R 与治疗前差异无显著性(P>0.95)。结论急性乙醇中毒与急性一氧化碳中毒均可致 sIL-2R 增高。经用糖皮质激素治疗后 sIL-2R 降低较非糖皮质激素治疗更明显。故糖皮质激素治疗有免疫异常的急性中毒尤其是无特效解毒剂治疗的急性中毒是切实可行而有效的。

The clinical significance of detecting serum soluble interleukin 2 receptor in patients with acute poisoning

Objective To investigate the relationship between serum soluble interleukin 2 receptor(sIL-2R)levels and acute poisoning.Methods Serum sIL-2R levels in 80 acute poisoning subjects and 20normal control subjects were measured with enzyme linked immunosorbent assay(ELISA).80 subjects ofacute poisoning were divided into 4 groups:acute sedative hypnotic poisoning(SH)(n=20),acute alcoholpoisoning(AL)(n=20),acute carbon monoxide poisoning(CO)(n=20),and acute farm insectiside poi-soning(FI)(n=20).Results The levels of serum sIL-2R in AL and CO were significantly higher thanthose in controls(P<0.01),and SH(P<0.05).No significant differences were shown between SH,FIand controls(P>0.05)as well as among other poisoning groups,The levels of sIL-2R were markedly de-creased in AL and CO after treatment(P<0.05 and P<0.01 respectively).There were no significant differ-ences in SH,FI before and after treatment(P>0.05).Conclusion The significant elevation of serum sIL-2R levels wrer shown in AL and CO.Tbe levels of slL-2R decreased after treatment with glucocorticoidmuch more markedly than those after treatment with non-glucocorticoid.So the treatment of glucocorticoid isfeasidble and effective for acute poisoning with immuue disorder,especially for those without any specific anti-dote.