Behavioral effects of basal forebrain cholinergic lesions in young adult and aging rats |
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Authors: | Paban Véronique Chambon Caroline Jaffard Magali Alescio-Lautier Béatrice |
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Affiliation: | Laboratoire de Neurobiologie Intégrative et Adaptative, Université d'Aix-Marseille I, Marseille, France. paban@up.univ-mrs.fr |
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Abstract: | The interactive effects of age and cholinergic damage were assessed behaviorally in young and middle-aged rats. Rats were lesioned at either 3 or 17 months of age by injection of 192 IgG-saporin immunotoxin into the medial septum and the nucleus basalis magnocellularis, and they were then tested on a range of behavioral tasks: a nonmatching-to-position task in a T-maze, an object-recognition task, an object-location task, and an open-field activity test. Depending on the task used, only an age or a lesion effect was observed, but there was no Age X Lesion interaction. Middle-aged and young rats responded to the cholinergic lesions in the same manner. These results show that in the middle-aged rats in which cholinergic transmission was affected, additional injury to the system was not always accompanied by major cognitive dysfunctions. |
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