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| MDR1基因多态性及表达与急性白血病患者预后相关性的研究进展 | |
| 引用本文： | 王丹,克晓燕,胡永芳. MDR1基因多态性及表达与急性白血病患者预后相关性的研究进展[J]. 中国药理学通报, 2007, 23(6): 707-710 |
| 作者姓名： | 王丹 克晓燕 胡永芳 |
| 作者单位： | 1. 北京大学,第三医院药剂科,北京,100083;北京大学,药学院药事管理与临床药学系,北京,100083 2. 北京大学,第三医院血液科,北京 100083 3. 北京大学,第三医院药剂科,北京,100083 |
| 摘 要： | 多药耐药(multidrug resistant,MDR)是肿瘤细胞耐药的常见方式,也是急性白血病患者化疗失败和复发的主要原因。近年来,国外许多学者围绕MDR1基因多态性及MDR1 mRNA表达与其编码蛋白(P-glycoprotein,P-gp)表达和功能相关性进行了大量研究,多数研究表明P-gp与急性白血病的化疗预后相关。该文就国外关于MDR1基因多态性与急性白血病患者预后相关性的最新研究进展进行了总结,以期对急性白血病患者的治疗与预后评估有所帮助。 |
| 关 键 词： | 急性白血病 MDR1基因多态性 完全缓解率 无进展生存期 总生存期 |
| 文章编号： | 1001-1978（2007）06-0707-04 |
| 修稿时间： | 2007-01-13 |
Correlation between MDR1 genetic polymorphism and prognosis in acute leukemia |
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| WANG Dan,KE Xiao-yan,HU Yong-fang. Correlation between MDR1 genetic polymorphism and prognosis in acute leukemia[J]. Chinese Pharmacological Bulletin, 2007, 23(6): 707-710 | |
| Authors: | WANG Dan KE Xiao-yan HU Yong-fang |
| Affiliation: | 1. Dept of Pharmacy, Peking University Third Hospital,2. Dept of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences Peking University 3. Dept of Hematology, Peking University Third Hospital,Beijing 100083, China |
| Abstract: | Multidrug resistance is a common form of drug resistance of tumors and one main reason for chemotherapy′s failure and recrudescence of acute leukemia. In recent years,substantial studies addressed the different aspects about MDR1,including MDR1 genetic polymorphism,mRNA/protein expression as well as the function of its coding protein (P-gp).This paper reviewed recent advances about the relation between MDR1 genetic polymorphism and acute leukemia prognosis with the aim to improve acute leukemia curing and chemotherapy outcome evaluating in China. |
| Keywords: | acute leukemia MDR1 genetic polymorphism complete remission free-event survival overall survival |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |